Evidence map›Paper›PMID 32528304›Full record

ArticleFrontiers in physiology2020

High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts.

Vineesh Kappadan, Saba Telele, Ilija Uzelac, Flavio Fenton, Ulrich Parlitz, Stefan Luther, Jan Christoph

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Mapping and ablation of ventricular fibrillation substrate.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  3. Article
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  11. Article
  12. Article
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  14. Article
  15. Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Review
  16. Complex repolarization dynamics in ex vivo human ventricles are independent of the restitution properties.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  17. Article
  18. Paralysis by analysis: Overcoming cardiac contraction with computer vision.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Virtual blebbistatin: A robust and rapid software approach to motion artifact removal in optical mapping of cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Optical mapping of contracting hearts.The Journal of physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Vineesh KappadanResearch Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Saba TeleleResearch Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Ilija UzelacSchool of Physics, Georgia Institute of Technology, Atlanta, GA, United States.
Flavio FentonSchool of Physics, Georgia Institute of Technology, Atlanta, GA, United States.
Ulrich ParlitzResearch Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Stefan LutherResearch Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Jan ChristophResearch Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.
Max Planck Institute for Dynamics and Self-Organization · DEGeorgia Institute of Technology · USGerman Centre for Cardiovascular Research · DE

Funding

Integrative High-Resolution Experimental and Multiscale Modeling of Arrhythmias to Optimize Low Energy Anti-fibrillation Pacing (LEAP)R01HL143450 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Flavio H Fenton · 2018 to 2026
$3.2M
NHLBI NIH HHS R01 HL143450
6 · The paper itself

Abstract

Optical mapping is a high-resolution fluorescence imaging technique, that uses voltage- or calcium-sensitive dyes to visualize electrical excitation waves on the heart surface. However, optical mapping is very susceptible to the motion of cardiac tissue, which results in so-called

Indexed as

Blebbistatincomputer visionelectromechanicsfluorescence imagingmotion correctionmotion trackingoptical mappingventricular fibrillation

Identifiers

PMID32528304
PMCPMC7264405
OpenAlexW3026478374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.