ArticleFrontiers in pharmacology2020
Effects of
Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Lycium Barbarum Polysaccharides Alleviate Parkinson's Disease-Induced Neurodegeneration by Up-Regulating USP10 to Modulate Endoplasmic Reticulum Stress.Neurochemical research · 2026Article
- Phytochemical properties ofFrontiers in pharmacology · 2026Article
- Efficacy of Lingji Formula in the Treatment of Male Infertility in Obese Men: Study Protocol for a Randomized Controlled Trial.International journal of general medicine · 2026Article
- Mechanisms of Leydig Cell Aging and Obesity-Related Hypogonadism in Men: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Therapeutic mechanisms of Lycii Fructus in male infertility: a comprehensive review.Frontiers in pharmacology · 2025Review
- The Beneficial Effect ofAnalytical cellular pathology (Amsterdam) · 2025Article
- Article
- Genomic Analysis of Romanian Lycium Genotypes: ExploringInternational journal of molecular sciences · 2024Article
- Pathophysiology of obesity-related infertility and its prevention and treatment by potential phytotherapeutics.International journal of obesity (2005) · 2024Review
- Mulberry Leaf Polysaccharides Attenuate Oxidative Stress Injury in Peripheral Blood Leukocytes by Regulating Endoplasmic Reticulum Stress.Antioxidants (Basel, Switzerland) · 2024Article
- Goji Berry in the Diet of the Rabbit Buck: Effects on Semen Quality, Oxidative Status and Histological Features of the Reproductive Tract.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- Distinct Role ofPharmaceuticals (Basel, Switzerland) · 2023Review
- Hypoglycemic Effect of Exopolysaccharide fromFoods (Basel, Switzerland) · 2022Article
- Article
- Article
- Effects of Traditional Chinese Medication-Based Bioactive Compounds on Cellular and Molecular Mechanisms of Oxidative Stress.Oxidative medicine and cellular longevity · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of obesity-associated decline in male fertility has increased over the years.
aimThis study aimed to investigate the protective effect of LBP on the testes of obese mice.
methodsFollowing administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.
resultsOur results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.
conclusionOur results show that LBP is a potential novel drug for preventing male infertility caused by obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.