Evidence map›Paper›PMID 32528251›Full record

ArticleFrontiers in cellular neuroscience2020

HCN2 Channel-Induced Rescue of Brain Teratogenesis

Vaibhav P Pai, Javier Cervera, Salvador Mafe, Valerie Willocq, Emma K Lederer, Michael Levin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 57 citations in OpenAlex.

  1. Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026
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  7. The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next-Generation Biomedicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  8. Article
  9. Article
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  11. Inter-organ communication during tissue regeneration.Development (Cambridge, England) · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Vaibhav P PaiAllen Discovery Center at Tufts University, Medford, MA, United States.
Javier CerveraDepartament de Termodinamica, Facultat de Fisica, Universitat de Valencia, Burjassot, Spain.
Salvador MafeDepartament de Termodinamica, Facultat de Fisica, Universitat de Valencia, Burjassot, Spain.
Valerie WillocqAllen Discovery Center at Tufts University, Medford, MA, United States.
Emma K LedererAllen Discovery Center at Tufts University, Medford, MA, United States.
Michael LevinAllen Discovery Center at Tufts University, Medford, MA, United States.
Tufts University · USUniversitat de València · ES

Funding

Electrotherapeutic strategies for connective tissue repairR01AR061988 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI HUNG, CLARK T., KAPLAN, DAVID L. · 2011 to 2015
$3.3M
Tissue Regeneration by Biophysical SignalingR01AR055993 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L., LEVIN, MICHAEL · 2010 to 2018
$3.2M
NIAMS NIH HHS R01 AR055993NIAMS NIH HHS R01 AR061988
6 · The paper itself

Abstract

Embryonic exposure to the teratogen nicotine results in brain defects, by disrupting endogenous spatial pre patterns necessary for normal brain size and patterning. Extending prior work in

Indexed as

bioelectricion channellong-rangenicotinenon-localregenerative medicineteratogen

Identifiers

PMID32528251
PMCPMC7264377
OpenAlexW3027101540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.