Evidence map›Paper›PMID 32528179›Full record

ArticleNature2020

Structure of a nascent membrane protein as it folds on the BAM complex.

David Tomasek, Shaun Rawson, James Lee, Joseph S Wzorek, Stephen C Harrison, Zongli Li, Daniel Kahne

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 170 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  10. Article
  11. Article
  12. Review
  13. A mechanism for substrate quality control in outer membrane protein assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Review
  17. Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Review
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

David TomasekDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1212-4601
Shaun RawsonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2973-2630
James LeeDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Joseph S WzorekDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Stephen C HarrisonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. harrison@crystal.harvard.edu.ORCID http://orcid.org/0000-0001-7215-9393
Zongli LiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. zongli_li@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1237-7556
Daniel KahneDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. kahne@chemistry.harvard.edu.ORCID http://orcid.org/0000-0002-8296-1424
Harvard University · USHoward Hughes Medical Institute · US

Funding

Outer Membrane Biogenesis: New Antibiotic TargetsR01AI081059 · NIAID · HARVARD UNIVERSITY · PI Daniel Kahne · 2009 to 2026
$9.5M
Studies Toward Hybrid Glycopeptide AntibioticsR01GM066174 · NIGMS · PRINCETON UNIVERSITY · PI KAHNE, DANIEL · 2002 to 2018
$8.9M
Substrate Recognition by the Bam ComplexF32GM108258 · NIGMS · HARVARD UNIVERSITY · PI WZOREK, JOSEPH · 2014 to 2015
$106k
Mapping the pathway of membrane β-barrel protein folding by the Bam complex.F31GM116210 · NIGMS · HARVARD UNIVERSITY · PI LEE, JAMES · 2016 to 2017
$63k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI081059NIGMS NIH HHS F31 GM116210NIGMS NIH HHS F32 GM108258NIGMS NIH HHS R01 GM066174
6 · The paper itself

Abstract

Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of membranes. The outer membrane contains proteins with a β-barrel structure

Indexed as

Protein FoldingBacterial Outer Membrane ProteinsChloroplastsEscherichia coli ProteinsGram-Negative BacteriaHydrogen BondingMembrane ProteinsMitochondriaModels, MolecularMultiprotein ComplexesProtein ConformationSubstrate SpecificityBacterial Outer Membrane ProteinsBamA protein, E coliEscherichia coli ProteinsMembrane ProteinsMultiprotein Complexes

Identifiers

PMID32528179
PMCPMC7367713
OpenAlexW3035643422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.