ArticleNature2020
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
121 citing papers in PubMed, 214 citations in OpenAlex.
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- The structure of the dopamine DScience advances · 2026Article
- Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)-VK4-116, as a Non-Opioid Medication for the Treatment of Opioid Use Disorder.Medicinal research reviews · 2026Review
- Efficient experimental characterization of the GPCRome via deep receptor scanning.Nature communications · 2026Article
- Emergence of specific binding and catalysis from a designed generalist binding protein.Nature chemistry · 2026Article
- Review
- A structural overview of G-protein-coupled receptors in neurological disorders.Acta pharmacologica Sinica · 2026Review
- DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy.Nature biomedical engineering · 2026Article
- Study of the Mechanism by Which Shenfu Injection Regulates Cardiomyocyte Hypertrophy Based on Dopamine Receptor D2-Mediated Mitochondrial Fission.Anatolian journal of cardiology · 2026Article
- Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms.BMC biology · 2026Article
- Strategic advances for cryo-EM structural studies of small (<100 kDa) GPCRs.Communications biology · 2026Review
- Engineering Nanocarriers for Dopamine Stabilization and Targeted Brain Delivery: Mechanisms, Approaches and Translational Challenges.International journal of nanomedicine · 2026Review
- Structural insights into endogenous agonist selectivity of aminergic receptors from the octopamine βPNAS nexus · 2025Article
- FDA Drug Repurposing Uncovers Modulators of Dopamine DJournal of medicinal chemistry · 2025Article
- The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Netrin-1 Inhibits Neuroinflammation by Modulating DRD2/GSK3β Signaling and Suppressing ROS in a Parkinson's Disease Model.CNS neuroscience & therapeutics · 2025Article
- Stabilized DNature communications · 2025Article
- Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis.bioRxiv : the preprint server for biology · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Jie YinDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kuang-Yui M ChenInstitute of Bioengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0551-744X
Mary J ClarkDepartment of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-1176-5626
Mahdi HijaziInstitute of Bioengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Punita KumariDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiao-Chen BaiDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4234-5686
Roger K SunaharaDepartment of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA. rsunahara@ucsd.edu.ORCID http://orcid.org/0000-0003-1702-8619
Patrick BarthInstitute of Bioengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. patrick.barth@epfl.ch.ORCID http://orcid.org/0000-0002-0744-6844
Daniel M RosenbaumDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA. dan.rosenbaum@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-7174-4993
École Polytechnique Fédérale de Lausanne · CHThe University of Texas Southwestern Medical Center · USUniversity of California San Diego · USSouthwestern Medical Center · US
Funding
Structure and dynamics of G protein coupled receptor-G protein complexesR01GM083118 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOBILKA, BRIAN K, SKINIOTIS, GEORGIOS · 2008 to 2023
$8.3MHOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0MStructural mechanisms of Scap/SREBP signaling in membrane homeostasisR35GM136387 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel Rosenbaum · 2020 to 2026
$3.0MEXPLORING STRUCTURE AND SEQUENCE SPACES OF G PROTEIN-COUPLED RECEPTOR SIGNALINGR01GM097207 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BARTH, PATRICK DANIEL, WENSEL, THEODORE G · 2012 to 2020
$2.8MStructural and Functional Analyses of the Full-length Insulin Receptor (IR) and Type 1 Insulin-like Growth Factor Receptor (IGF1R) in the Liganded Active StateR01GM136976 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BAI, XIAOCHEN · 2020 to 2024
$1.8MNIGMS NIH HHS R01 GM083118NIGMS NIH HHS R01 GM097207NIGMS NIH HHS R01 GM136976NIGMS NIH HHS R35 GM136387NIGMS NIH HHS T32 GM008280
Abstract
The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson's disease
Indexed as
Cryoelectron MicroscopyMembranes, ArtificialBromocriptineDopamineGTP-Binding Protein alpha Subunits, Gi-GoHumansMembrane LipidsModels, MolecularProtein ConformationReceptors, Dopamine D2Signal TransductionBromocriptineDopamineGTP-Binding Protein alpha Subunits, Gi-GoMembrane LipidsMembranes, ArtificialReceptors, Dopamine D2
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.