ArticleScientific reports2020
A treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in 15
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 57 citations in OpenAlex.
- A refined phylochronology of the second plague pandemic in Western Eurasia.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Insights into infectious diseases through ancient pathogen genomics.Nature reviews. Microbiology · 2026Review
- Recent Microbial Evolutionary Insights From Metagenomics.Genome biology and evolution · 2026Review
- Molecular Diagnosis of Syphilis in Brazilian Ambulatory Patients: Detection ofMicroorganisms · 2026Article
- Diagnostic Methods Used in Detecting Syphilis in Paleopathological Research-A Literature Review.Diagnostics (Basel, Switzerland) · 2025Review
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- Insights into Treponema pallidum genomics from modern and ancient genomes using a novel mapping strategy.BMC biology · 2025Article
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- Metagenomic and paleopathological analyses of a historic documented collection explore ancient dental calculus as a diagnostic tool.Scientific reports · 2024Article
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- The final plague outbreak in Scotland 1644-1649: Historical, archaeological, and genetic evidence.PloS one · 2024Article
- From the Ground Up: A Multidisciplinary Approach to Past Fertility and Population Narratives.Human nature (Hawthorne, N.Y.) · 2023Article
- 14th century Yersinia pestis genomes support emergence of pestis secunda within Europe.PLoS pathogens · 2023Article
- Ancient pathogens provide a window into health and well-being.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14Cell · 2022Article
- Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens.Epidemiologia (Basel, Switzerland) · 2022Review
- Article
- An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.Genome biology · 2022Article
- Effects ofFrontiers in microbiology · 2022Article
- Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis.Nature microbiology · 2021Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Developments in techniques for identification of pathogen DNA in archaeological samples can expand our resolution of disease detection. Our application of a non-targeted molecular screening tool for the parallel detection of pathogens in historical plague victims from post-medieval Lithuania revealed the presence of more than one active disease in one individual. In addition to Yersinia pestis, we detected and genomically characterized a septic infection of Treponema pallidum pertenue, a subtype of the treponemal disease family recognised as the cause of the tropical disease yaws. Our finding in northern Europe of a disease that is currently restricted to equatorial regions is interpreted within an historical framework of intercontinental trade and potential disease movements. Through this we offer an alternative hypothesis for the history and evolution of the treponemal diseases, and posit that yaws be considered an important contributor to the sudden epidemic of late 15
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