Evidence map›Paper›PMID 32528079›Full record

ReviewHeredity2020

Applying genomic resources to accelerate wheat biofortification.

Muhammad Waqas Ali, Philippa Borrill

Open access · hybridAbstract readReview
In one paragraph

Review in Heredity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Stable pleotropic loci controlling the accumulation of multiple nutritional elements in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  3. Review
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  13. Genomic selection can accelerate the biofortification of spring wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Muhammad Waqas AliSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-2826-4545
Philippa BorrillSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. P.Borrill@bham.ac.uk.ORCID http://orcid.org/0000-0002-7623-8256
University of Birmingham · GB

Funding

Royal Society RGS\R1\191163
6 · The paper itself

Abstract

Wheat has low levels of the micronutrients iron and zinc in the grain, which contributes to 2 billion people suffering from micronutrient deficiency globally. While wheat flour is commonly fortified during processing, an attractive and more sustainable solution is biofortification, which could improve micronutrient content in the human diet, without the sustainability issues and costs associated with conventional fortification. Although many studies have used quantitative trait loci mapping and genome-wide association to identify genetic loci to improve micronutrient contents, recent developments in genomics offer an opportunity to accelerate marker discovery and use gene-focussed approaches to engineer improved micronutrient content in wheat. The recent publication of a high-quality wheat genome sequence, alongside gene expression atlases, variation datasets and sequenced mutant populations, provides a foundation to identify genetic loci and genes controlling micronutrient content in wheat. We discuss how novel genomic resources can identify candidate genes for biofortification, integrating knowledge from other cereal crops, and how these genes can be tested using gene editing, transgenic and TILLING approaches. Finally, we highlight key challenges remaining to develop wheat cultivars with high levels of iron and zinc.

Indexed as

BiofortificationGenomicsTriticumFlourGenome, Plant

Identifiers

PMID32528079
PMCPMC7784878
OpenAlexW3034377594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.