ArticleScientific reports2020
Pro-inflammatory markers and fatigue in patients with depression: A case-control study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Activation of the interleukin-23/Th17 axis in major depression: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Peripheral Inflammatory Markers in Subtypes and Core Features of Depression: A Systematized Review.Psychopathology · 2023Pooled it
- Evaluation of inflammatory cytokines in drug-naïve major depressive disorder: A systematic review and meta-analysis.International journal of immunopathology and pharmacologyPooled it
- Effects of left anodal transcranial direct current stimulation on hypothalamic-pituitary-adrenal axis activity in depression: a randomized controlled pilot trial.Scientific reports · 2023Trial
- Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Acupuncture in remodeling the tumor microenvironment: current status and challenges.Frontiers in immunology · 2026Review
- Evaluating the Causal Role of Genetically Inferred Immune Cells and Inflammatory Cytokines on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Biomedicines · 2025Article
- Acupoint massage: a comprehensive descriptive review of its forms, applications, and underlying mechanisms.Chinese medicine · 2025Review
- Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls.Scientific reports · 2025Article
- Depressed mood affects the process of biological aging, analyses from the NHANES dataset.Frontiers in aging · 2025Review
- The impact of a ketogenic diet on weight loss, metabolism, body composition and quality of life.iScience · 2024Article
- The associations between dairy product intake, fatigue status, and physical activity among postpartum women in Saudi Arabia: a cross-sectional study.BMC public health · 2024Article
- Inflammatory biomarkers in depression: scoping review.BJPsych open · 2024Article
- How is inflammation biology truly associated with depression in patients with stable coronary heart disease?: Insights from the heart and Soul study.Brain, behavior, & immunity - health · 2024Article
- Fatigue, Toll-Like Receptor 4, and Pro-Inflammatory Cytokines in Adults With Subarachnoid Hemorrhage: A 6-Month Longitudinal Study.Biological research for nursing · 2024Review
- Moderating effect of negative emotion differentiation in chronic stress and fatigue among Chinese employees.Frontiers in psychology · 2024Article
- Acupuncture improves immunity and fatigue after chemotherapy in breast cancer patients by inhibiting the Leptin/AMPK signaling pathway.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers.International wound journal · 2023Article
- A Study of Diurnal Cortisol Adaptations in Sleep-Deprived Firefighters During a 72-Hour Work Shift: A Case Series.Cureus · 2023Article
- IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance.Scandinavian journal of medicine & science in sports · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to investigate differences between depressed subjects (PG) and non-depressed healthy control participants (HCG) with regard to fatigue dimensions and inflammation. For this purpose, 43 participants in the PG and 51 participants in the HCG were included in the study. IL-6, IL-1β, TNF-α, IFN-γ, and CRP were assessed in venous blood samples. Fatigue and depression were assessed using the FIS-D and BDI-FS questionnaires. Main results showed higher BDI-FS values in PG. Moreover, PG showed mean differences for fatigue dimensions when compared to the HCG. For the pro-inflammatory markers, a moderate group effect was found between PG and HCG which was mainly caused by IL-6. Correlations between TNF-α and BDI-FS, TNF-α and cognitive fatigue, TNF-α and psychosocial fatigue were found within the PG. In the HCG, correlations were found between IL-6, TNF-α and somatic fatigue, as well as IL-6 and cognitive fatigue. Significant correlations were found between the psychological variables in both groups. All results were controlled for the confounding variables gender, age, BMI and multiple comparisons. These results suggest the presence of inflammation in both depression and fatigue. However, each correlates with different pro-inflammatory parameters, suggesting a biological heterogeneity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.