ArticleScientific reports2020
Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of Klebsiella pneumoniae.NPJ systems biology and applications · 2022Pooled it
- Host-derived stimuli alter intracellular calcium levels inApplied and environmental microbiology · 2026Article
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- Transcriptome-Integrated Metabolic Modeling Identifies Candidate Metabolic Adjuvants in Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Calcium regulation ofApplied and environmental microbiology · 2026Article
- MiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa.Nucleic acids research · 2026Article
- Genomic insights into 'Candidatus Pseudomonas auctus' JDE115, a soybean endophyte with expanded nutrient acquisition and biocontrol-related gene repertoires.BMC genomics · 2026Article
- Metagenomic analysis of antimicrobial resistance, virulence, and mobile genetic elements in the gut microbiota of Caprinae species.Communications biology · 2026Article
- Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence.FEMS microbes · 2026Article
- In silico analysis of hypothetical proteins in Pseudomonas aeruginosa PAC1: Structural and functional insights.Journal, genetic engineering & biotechnology · 2025Article
- Drosophila attraction, colonization, contagion, and mortality by Pseudomonas spp. and toxicity of their biosurfactants.Applied microbiology and biotechnology · 2025Article
- Genetic and virulence factors behind the success of high-riskFrontiers in microbiology · 2025Article
- Genomic virulence markers are associated with severe outcomes in patients with Pseudomonas aeruginosa bloodstream infection.Communications medicine · 2024Article
- Secondary metabolite profiling ofmSystems · 2024Article
- Isolation, identification and pathogenicity of local entomopathogenic bacteria as biological control agents against the wild cochineal Dactylopius opuntiae (Cockerell) on cactus pear in Morocco.Scientific reports · 2023Article
- Study of peripheral domains in structure-function of isocitrate lyase (ICL) from Pseudomonas aeruginosa.World journal of microbiology & biotechnology · 2023Article
- The transcriptional regulators of virulence forGenes & diseases · 2023Review
- Probiotics: insights and new opportunities forCritical reviews in microbiology · 2023Review
- Synergistic Antibacterial Activity of Benzalkonium Bromide and Cu-Bearing Duplex Stainless Steel againstMicroorganisms · 2023Article
- Intestinal Immune Deficiency and Juvenile Hormone Signaling Mediate a Metabolic Trade-off in AdultMetabolites · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the role of core metabolism genes in bacterial virulence - independently of their effect on growth - we correlated the genome, the transcriptome and the pathogenicity in flies and mice of 30 fully sequenced Pseudomonas strains. Gene presence correlates robustly with pathogenicity differences among all Pseudomonas species, but not among the P. aeruginosa strains. However, gene expression differences are evident between highly and lowly pathogenic P. aeruginosa strains in multiple virulence factors and a few metabolism genes. Moreover, 16.5%, a noticeable fraction of the core metabolism genes of P. aeruginosa strain PA14 (compared to 8.5% of the non-metabolic genes tested), appear necessary for full virulence when mutated. Most of these virulence-defective core metabolism mutants are compromised in at least one key virulence mechanism independently of auxotrophy. A pathway level analysis of PA14 core metabolism, uncovers beta-oxidation and the biosynthesis of amino-acids, succinate, citramalate, and chorismate to be important for full virulence. Strikingly, the relative expression among P. aeruginosa strains of genes belonging in these metabolic pathways is indicative of their pathogenicity. Thus, P. aeruginosa strain-to-strain virulence variation, remains largely obscure at the genome level, but can be dissected at the pathway level via functional transcriptomics of core metabolism.
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