Evidence map›Paper›PMID 32527842›Full record

ArticleAJNR. American journal of neuroradiology2020

Neurologic Involvement in COVID-19: Cause or Coincidence? A Neuroimaging Perspective.

A Pons-Escoda, P Naval-Baudín, C Majós, A Camins, P Cardona, M Cos, N Calvo

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
    Pooled it
  3. Pooled it
  4. Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Pooled it
  5. Pooled it
  6. Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  7. Neurological manifestations of coronavirus infections - a systematic review.Annals of clinical and translational neurology · 2020
    Pooled it
  8. Pooled it
  9. Article
  10. Review
  11. Neurological manifestation in COVID-19 disease with neuroimaging studies.American journal of neurodegenerative disease · 2023
    Review
  12. Article
  13. Central nervous system outcomes of COVID-19.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  14. Article
  15. COVID-19 and ischemic stroke.European journal of neurology · 2021
    Review
  16. Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19.medRxiv : the preprint server for health sciences · 2021
    Article
  17. Article
  18. Review
  19. COVID-19: Neuroimaging Features of a Pandemic.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
    Review
  20. Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease.medRxiv : the preprint server for health sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A Pons-EscodaFrom the Radiology Department (A.P.-E., P.N.-B., C.M., A.C., M.C., N.C.), Institut de Diagnòstic per la Imatge albert.pons.idi@gencat.cat.ORCID 0000-0003-4167-8291
P Naval-BaudínFrom the Radiology Department (A.P.-E., P.N.-B., C.M., A.C., M.C., N.C.), Institut de Diagnòstic per la Imatge.ORCID 0000-0002-8714-0764
C MajósFrom the Radiology Department (A.P.-E., P.N.-B., C.M., A.C., M.C., N.C.), Institut de Diagnòstic per la Imatge.ORCID 0000-0003-0468-5150
A CaminsFrom the Radiology Department (A.P.-E., P.N.-B., C.M., A.C., M.C., N.C.), Institut de Diagnòstic per la Imatge.ORCID 0000-0003-2678-8134
P CardonaNeurology Department (P.C.), Hospital Universitari de Bellvitge, Barcelona, Spain.ORCID 0000-0002-5849-1258
M CosFrom the Radiology Department (A.P.-E., P.N.-B., C.M., A.C., M.C., N.C.), Institut de Diagnòstic per la Imatge.ORCID 0000-0003-0827-7170
N CalvoFrom the Radiology Department (A.P.-E., P.N.-B., C.M., A.C., M.C., N.C.), Institut de Diagnòstic per la Imatge.ORCID 0000-0003-4284-2620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid spread of the coronavirus disease 2019 (COVID-19) pandemic has shaken hospitals worldwide. Some authors suggest that neurologic involvement could further complicate the disease. This descriptive study is a cross-sectional review of 103 patients diagnosed with COVID-19 who underwent neuroimaging (of a total of 2249 patients with COVID-19 in our center). Analyzed variables were neurologic symptoms and acute imaging findings. The most frequent symptoms that motivated neuroimaging examinations were mild nonfocal neurologic symptoms, code stroke (refers to patients presenting with signs and symptoms of stroke whose hyperacute assessment and care is prioritized), focal neurologic symptoms, postsedation encephalopathy, and seizures. No cases of encephalitis or direct central nervous system involvement were detected. Thirteen patients presented with acute ischemic events, and 7, with hemorrhagic events; however, most reported multiple vascular risk factors. Despite the large cohort of patients with COVID-19, we found a large number of symptomatic patients with negative neuroimaging findings, and no conclusions can be drawn concerning concrete associations between neuroimaging and COVID-19.

Indexed as

BetacoronavirusNeuroimagingAdultAgedAged, 80 and overCoronavirus InfectionsCOVID-19Cross-Sectional StudiesEncephalitisFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralRisk Factors

Identifiers

PMID32527842
PMCPMC7658883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.