Evidence map›Paper›PMID 32527840›Full record

ArticleAJNR. American journal of neuroradiology2020

Distinguishing Extravascular from Intravascular Ferumoxytol Pools within the Brain: Proof of Concept in Patients with Treated Glioblastoma.

R F Barajas, D Schwartz, H L McConnell, C N Kersch, X Li, B E Hamilton, J Starkey, D R Pettersson, J P Nickerson, J M Pollock and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  11. Programmed cell death, redox imbalance, and cancer therapeutics.Apoptosis : an international journal on programmed cell death · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 7 countries.

R F BarajasFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0001-5093-4168
D SchwartzFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0002-5578-8312
H L McConnellDepartments of Neurology (H.L.M., C.N.K., L.S., C.G.V., P.A., L.L.M., E.A.N.).ORCID 0000-0002-0505-6316
C N KerschDepartments of Neurology (H.L.M., C.N.K., L.S., C.G.V., P.A., L.L.M., E.A.N.).ORCID 0000-0003-4968-9817
X LiAdvanced Imaging Research Center (R.F.B. Jr, D.S., X.L., A.H., W.D.R.).ORCID 0000-0002-9283-3602
B E HamiltonFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0002-1881-9108
J StarkeyFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0002-4365-9871
D R PetterssonFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0002-3123-1747
J P NickersonFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0001-9995-2252
J M PollockFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0003-4317-779X
R F FuMedical Informatics and Clinical Epidemiology (R.F.F.).ORCID 0000-0003-4598-8211
A HorvathAdvanced Imaging Research Center (R.F.B. Jr, D.S., X.L., A.H., W.D.R.).ORCID 0000-0002-0396-2446
L SzidonyaFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0002-5687-7835
C G VarallyayFrom the Departments of Radiology (R.F.B. Jr, D.S., B.E.H., J.S., D.R.P., J.P.N., J.M.P., L.S., C.G.V.).ORCID 0000-0003-0640-5546
J J JaboinRadiation Medicine (J.J.J.).ORCID 0000-0002-5099-1055
A M RaslanNeurological Surgery (A.M.R., A.D., J.S.C., J.C., S.J.H., E.A.N.).ORCID 0000-0003-4936-1459
A DoganNeurological Surgery (A.M.R., A.D., J.S.C., J.C., S.J.H., E.A.N.).ORCID 0000-0002-4113-1619
J S CetasNeurological Surgery (A.M.R., A.D., J.S.C., J.C., S.J.H., E.A.N.).ORCID 0000-0001-6711-035X
J CiporenNeurological Surgery (A.M.R., A.D., J.S.C., J.C., S.J.H., E.A.N.).ORCID 0000-0001-7082-4513
S J HanNeurological Surgery (A.M.R., A.D., J.S.C., J.C., S.J.H., E.A.N.).ORCID 0000-0002-6944-3745
P AmbadyDepartments of Neurology (H.L.M., C.N.K., L.S., C.G.V., P.A., L.L.M., E.A.N.).ORCID 0000-0003-4812-0581
L L MuldoonDepartments of Neurology (H.L.M., C.N.K., L.S., C.G.V., P.A., L.L.M., E.A.N.).ORCID 0000-0001-5583-2304
R WoltjerPathology (R.W.).ORCID 0000-0003-0755-9846
W D RooneyAdvanced Imaging Research Center (R.F.B. Jr, D.S., X.L., A.H., W.D.R.).ORCID 0000-0003-0617-1540
E A NeuweltDepartments of Neurology (H.L.M., C.N.K., L.S., C.G.V., P.A., L.L.M., E.A.N.) neuwelte@ohsu.edu.ORCID 0000-0002-6679-6203
United States Nuclear Regulatory Commission · USJisc · GBAdvanced Imaging Research (United States) · USApath (United States) · USCancer Institute (WIA) · INFederal Medical Centre · NGJohnson & Johnson (Israel) · ILSemmelweis University · HU

Funding

Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
Two Compartment Models to Improve Brain Tumor TherapyR01CA137488 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 2008 to 2019
$7.3M
Opening of the Blood-Brain Barrier to Antitumor AgentsR01CA199111 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 2016 to 2020
$3.1M
NCATS NIH HHS KL2 TR002370NCI NIH HHS L30 CA220897NCI NIH HHS R01 CA137488NCI NIH HHS R01 CA199111
6 · The paper itself

Abstract

background and purposeGlioblastoma-associated macrophages are a major constituent of the immune response to therapy and are known to engulf the iron-based MR imaging contrast agent, ferumoxytol. Current ferumoxytol MR imaging techniques for localizing macrophages are confounded by contaminating intravascular signal. The aim of this study was to assess the utility of a newly developed MR imaging technique, segregation and extravascular localization of ferumoxytol imaging, for differentiating extravascular-from-intravascular ferumoxytol contrast signal at a delayed 24-hour imaging time point. MATERIALS AND

methodsTwenty-three patients with suspected post-chemoradiotherapy glioblastoma progression underwent ferumoxytol-enhanced SWI. Segregation and extravascular localization of ferumoxytol imaging maps were generated as the voxelwise difference of the delayed (24 hours) from the early (immediately after administration) time point SWI maps. Continuous segregation and extravascular localization of ferumoxytol imaging map values were separated into positive and negative components. Image-guided biologic correlation was performed.

resultsNegative segregation and extravascular localization of ferumoxytol imaging values correlated with early and delayed time point SWI values, demonstrating that intravascular signal detected in the early time point persists into the delayed time point. Positive segregation and extravascular localization of ferumoxytol imaging values correlated only with delayed time point SWI values, suggesting successful detection of the newly developed extravascular signal.

conclusionsSegregation and extravascular localization of ferumoxytol MR imaging improves on current techniques by eliminating intrinsic tissue and intravascular ferumoxytol signal and may inform glioblastoma outcomes by serving as a more specific metric of macrophage content compared with uncorrected T1 and SWI techniques.

Indexed as

AdultArtifactsBrain NeoplasmsContrast MediaFemaleFerrosoferric OxideGlioblastomaHumansImage Interpretation, Computer-AssistedMacrophagesMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingProof of Concept StudyContrast MediaFerrosoferric Oxide

Identifiers

PMID32527840
PMCPMC7357650
OpenAlexW3035173393

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.