ArticleeNeuro
The Reuniens and Rhomboid Nuclei Are Required for Acquisition of Pavlovian Trace Fear Conditioning in Rats.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles.Human brain mapping · 2025Article
- Acquisition of trace fear conditioning without functional nucleus reuniens did not require dorsal or ventral hippocampus NMDA receptor activation in male Long-Evans rats.The international journal of neuropsychopharmacology · 2025Article
- The midline thalamic nucleus reuniens promotes compulsive-like grooming in rodents.Translational psychiatry · 2025Article
- Thalamo-hippocampal pathway regulates incidental memory capacity in mice.Nature communications · 2022Article
- Prefrontal projections to the nucleus reuniens signal behavioral relevance of stimuli during associative learning.Scientific reports · 2022Article
- Functional Reuniens and Rhomboid Nuclei Are Required for Proper Acquisition and Expression of Cued and Contextual Fear in Trace Fear Conditioning.The international journal of neuropsychopharmacology · 2022Article
- Mastication stimuli enhance the learning ability of weaning-stage rats, altering the hippocampal neuron transcriptome and micromorphology.Frontiers in behavioral neuroscience · 2022Article
- Neural Oscillations in Aversively Motivated Behavior.Frontiers in behavioral neuroscience · 2022Review
- Chemogenetic inactivation of the nucleus reuniens impairs object placement memory in female mice.Neurobiology of learning and memory · 2021Article
- The nucleus reuniens orchestrates prefrontal-hippocampal synchrony during spatial working memory.Neuroscience and biobehavioral reviews · 2021Review
- Efferent projections of CGRP/Calca-expressing parabrachial neurons in mice.The Journal of comparative neurology · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reuniens (Re) and rhomboid (Rh) nuclei (ReRh) of the midline thalamus interconnects the hippocampus (HPC) and the medial prefrontal cortex (mPFC). Several studies have suggested that the ReRh participates in various cognitive tasks. However, little is known about the contribution of the ReRh in Pavlovian trace fear conditioning, a procedure with a temporal gap between the conditioned stimulus (CS) and the unconditioned stimulus (US), and therefore making it harder for the animals to acquire. Because the HPC and mPFC are involved in trace, but not delay, fear conditioning and given the role of the ReRh in mediating this neurocircuitry, we hypothesized that ReRh inactivation leads to a learning deficit only in trace conditioning. In a series of experiments, we first examined the c-Fos expression in male Long-Evans rats and established that the ReRh was recruited in the encoding, but not the retrieval phase, of fear memory. Next, we performed behavioral pharmacology experiments and found that ReRh inactivation impaired only the acquisition, but not the consolidation or retrieval, of trace fear. However, although the ReRh was recruited during the encoding of delay fear demonstrated by c-Fos results, ReRh inactivation in any phases did not interfere with delay conditioning. Finally, we found that trace fear acquired under ReRh inactivation reprised when the ReRh was brought off-line during retrieval. Together, our data revealed the essential role of the ReRh in a learning task with temporally discontinuous stimuli.
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