Evidence map›Paper›PMID 32527675›Full record

Trial reportJournal of autoimmunity2020

SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients.

M Zen, E Fuzzi, D Astorri, F Saccon, R Padoan, L Ienna, G Cozzi, R Depascale, E Zanatta, M Gasparotto and 13 more

Abstract readClinical Trial
In one paragraph

Trial report in Journal of autoimmunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  6. TAX1BP1 regulates the apoptosis of renal tubular epithelial cells in ischemia/reperfusion injury via the NF-kB/PMAIP1 signaling pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

M ZenDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
E FuzziDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
D AstorriDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
F SacconDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
R PadoanDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
L IennaDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
G CozziDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
R DepascaleDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
E ZanattaDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
M GasparottoDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
F BenvenutiDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
S BindoliDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
M GattoDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
M FelicettiDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
A OrtolanDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
D CampanielloDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
M LarosaDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
M LorenzinDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
R RamondaDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
P SfrisoDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
F SchiavonDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
L IaccarinoDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy.
A DoriaDivision of Rheumatology, Department of Medicine DIMED, University of Padua, Italy. Electronic address: adoria@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy.

methodsBetween April 9th and April 25th

results916 patients (397 SLE, 182 AAV, 176 SSc, 111 RA, 50 IIM) completed the survey. 148 patients developed at least one symptom compatible with COVID-19 (cough 96, sore throat 64, fever 64, arthromyalgias 59, diarrhea 26, conjunctivitis 18, ageusia/hyposmia, 18). Among the 916 patients, 65 (7.1%) underwent SARS-CoV-2 nasopharyngeal swab (18 symptomatic and 47 asymptomatic), 2 (0.21%) tested positive, a proportion similar to that observed in the general population of the Veneto region. No deaths occurred. 31 patients (3.4%) withdrew ≥1 medication, mainly immunosuppressants or biologics. Adoption of social distancing was observed by 860 patients (93.9%), including 335 (36.6%) who adopted it before official lockdown.

conclusionsCOVID-19 incidence seems to be similar in our cohort compared to the general population. Adherence to therapy and to social distancing advise was high.

Indexed as

BetacoronavirusAdultAgedAutoimmune DiseasesCoronavirus InfectionsCOVID-19FemaleHumansImmunosuppressive AgentsItalyMaleMiddle AgedPandemicsPneumonia, ViralRheumatic DiseasesSARS-CoV-2Immunosuppressive AgentsANCA vasculitisIdiopathic inflammatory myopathiesRheumatoid arthritisSARS-CoV-2Systemic lupus erythematosusSystemic sclerosis

Identifiers

PMID32527675
PMCPMC7832807

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.