Evidence map›Paper›PMID 32527306›Full record

ArticleBMC infectious diseases2020

Is distance associated with tuberculosis treatment outcomes? A retrospective cohort study in Kampala, Uganda.

Katherine O Robsky, Seamus Hughes, Alex Kityamuwesi, Emily A Kendall, Peter James Kitonsa, David W Dowdy, Achilles Katamba

Abstract readComparative Study
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  4. Factors associated with successful treatment outcomes among tuberculosis patients in a district municipality of Vhembe, Limpopo.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
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  15. Article
  16. Tuberculosis Disability Adjusted Life Years, Colombia 2010-2018.Tropical medicine and infectious disease · 2022
    Article
  17. Geographic accessibility to health facilities predicts uptake of community-based tuberculosis screening in an urban setting.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherine O RobskyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. krobsky1@jhu.edu.ORCID http://orcid.org/0000-0001-7789-5779
Seamus HughesJohns Hopkins School of Medicine, Baltimore, USA.
Alex KityamuwesiUganda Tuberculosis Implementation Research Consortium, Kampala, Uganda.
Emily A KendallUganda Tuberculosis Implementation Research Consortium, Kampala, Uganda.
Peter James KitonsaUganda Tuberculosis Implementation Research Consortium, Kampala, Uganda.
David W DowdyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Achilles KatambaUganda Tuberculosis Implementation Research Consortium, Kampala, Uganda.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Hotspot versus clinic-based active case finding for TB in Uganda: A pragmatic randomized trialR01HL138728 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI David Wesley Dowdy, Emily A Kendall · 2017 to 2026
$5.4M
Translational modeling of individual- and population-level outcomes of novel tuberculosis drug regimensK08AI127908 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KENDALL, EMILY A · 2017 to 2021
$879k
FIC NIH HHS D43 TW010540Johns Hopkins Bloomberg School of Public Health Center for Global Health Established Field PlacementNHLBI NIH HHS R01 HL138728NHLBI NIH HHS R01HL138728NIAID NIH HHS K08 AI127908
6 · The paper itself

Abstract

backgroundChallenges accessing nearby health facilities may be a barrier to initiating and completing tuberculosis (TB) treatment. We aimed to evaluate whether distance from residence to health facility chosen for treatment is associated with TB treatment outcomes.

methodsWe conducted a retrospective cohort study of all patients initiating TB treatment at six health facilities in Kampala from 2014 to 2016. We investigated associations between distance to treating facility and unfavorable TB treatment outcomes (death, loss to follow up, or treatment failure) using multivariable Poisson regression.

resultsUnfavorable treatment outcomes occurred in 20% (339/1691) of TB patients. The adjusted relative risk (aRR) for unfavorable treatment outcomes (compared to treatment success) was 0.87 (95% confidence interval [CI] 0.70, 1.07) for patients living ≥2 km from the facility compared to those living closer. When we separately compared each type of unfavorable treatment outcome to favorable outcomes, those living ≥2 km from the facility had increased risk of death (aRR 1.42 [95%CI 0.99, 2.03]) but decreased risk for loss to follow-up (aRR 0.57 [95%CI 0.41, 0.78]) than those living within 2 km.

conclusionsDistance from home residence to TB treatment facility is associated with increased risk of death but decreased risk of loss to follow up. Those who seek care further from home may have advanced disease, but once enrolled may be more likely to remain in treatment.

Indexed as

Antitubercular AgentsFemaleHealth FacilitiesHealth Services AccessibilityHumansMaleRetrospective StudiesRiskTreatment OutcomeTuberculosisUgandaAntitubercular AgentsEpidemiologyGeographic information systemsHealth systems research

Identifiers

PMID32527306
PMCPMC7291553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.