ArticleBMC geriatrics2020
Hemoglobin concentration; a pathway to frailty.
Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Frailty and pituitary surgery: a systematic review.Pituitary · 2025Pooled it
- Bellmunt Risk Score as a Prognostic Tool in Metastatic Castration-Resistant Prostate Cancer Survival.JAMA network open · 2026Trial
- Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile.Immunity & ageing : I & A · 2026Article
- Frailty phenotype in adults with sickle cell disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Performance of exercise transcutaneous oximetry versus imaging at the buttock, thigh and calf level for the diagnosis of peripheral artery disease.Clinical physiology and functional imaging · 2026Article
- U-shaped association between hemoglobin levels and cardiometabolic multimorbidity in older adults: a large-scale cross-sectional study.BMC geriatrics · 2026Article
- Association between admission hemoglobin-to-red blood cell distribution width ratio and stroke-associated pneumonia risk in acute ischemic stroke: effect modification by diabetes status.Frontiers in endocrinology · 2026Article
- Survival Prediction for Non-Asphyxia-Related Hypothermic Cardiac Arrest Patients After Extracorporeal Rewarming: Development of the HELP Score.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Article
- FINE, a novel laboratory-based frailty index for elderly patients: a retrospective descriptive study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.Frontiers in medicine · 2026Article
- Article
- Factors associated with hospitalization from a geriatric short-stay unit (OBI-GER): a retrospective cohort study.Aging clinical and experimental research · 2025Article
- Effect of multimodal home-based prehabilitation on objectively measured physical activity in patients undergoing elective cardiac or non-cardiac major surgery: secondary outcomes from a randomised controlled trial.Perioperative medicine (London, England) · 2025Article
- Article
- Association Between Preoperative Frailty Using Frailty Index-Laboratory Test and Clinical Outcomes in Older Adults Undergoing Brain Tumor Surgery.Nursing & health sciences · 2025Article
- Frailty in older adults: A systematic review of risk factors and early intervention pathways.Intractable & rare diseases research · 2025Review
- Incidence and influencing factors of postoperative frailty in elderly prostate cancer patients: a cross-sectional study.Frontiers in medicine · 2025Article
- Prevalence and factors associated with frailty among incident kidney transplant patients: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2025Article
- A Real-Time Web-Based Intervention with a Multicomponent Group-Based Program for Older Adults: Single-Arm Feasibility Study.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty and hemoglobin concentration, above what would be considered clinical anemia, are two common findings in older patients that lead to an increased risk of negative health outcomes. The objective of this study is to evaluate whether hemoglobin concentration is an independent predictor of frailty and investigate possible causal pathways with a focus on the relationship between inflammation or nutrition and hemoglobin concentration.
methods1829 community-dwelling participants aged 65 years or older who visited the Toulouse frailty day hospital during 2011 and 2016 were included in this analysis. Patients underwent a comprehensive geriatric assessment and had a blood sample taken. A series of multivariate logistic regression models were performed after minimizing potential influence from age, gender, kidney function, inflammation, cognition, nutritional status and certain socio-economic factors.
resultsHemoglobin concentration and frailty are significantly associated after minimizing potential influence from other covariates (p < 0.005). An increase in one point of hemoglobin concentration is associated with a 14% risk reduction of being frail (OR = 0.86, 95%IC = 0.79-0.94). There was no evidence of a significant causal relationship between inflammation and nutritional status in the relationship between hemoglobin concentration and frailty status (p > 0.005).
conclusionsHemoglobin concentration is strongly associated with frailty in older adults. These results can have potentially important implications for prevention policies targeting frailty by identifying potential patients with high risk of adverse outcomes and functional outcomes.
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