ArticleCirculation. Genomic and precision medicine2020
Genetic Basis and Prognostic Value of Exercise QT Dynamics.
Article in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Long-term association of ultra-short heart rate variability with cardiovascular events.Scientific reports · 2023Article
- Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events.European heart journal. Digital health · 2023Article
- Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- ECG T-Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low- and Moderate-Risk Populations.Journal of the American Heart Association · 2022Article
- Exercise Test for Patients with Long QT Syndrome.Acta Cardiologica Sinica · 2022Review
- Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.Human molecular genetics · 2021Article
- Bivariate Entropy Analysis of Electrocardiographic RR-QT Time Series.Entropy (Basel, Switzerland) · 2020Article
- Analysing electrocardiographic traits and predicting cardiac risk in UK biobank.JRSM cardiovascular diseaseReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundAbnormal QT interval responses to heart rate (QT dynamics) is an independent risk predictor for cardiovascular disease in patients, but its genetic basis and prognostic value in a population-based cohort have not been investigated.
methodsQT dynamics during exercise and recovery were derived in 56 643 individuals from UK Biobank without a history of cardiovascular events. Genome-wide association studies were conducted to identify genetic variants and bioinformatics analyses were performed to prioritize candidate genes. The prognostic value of QT dynamics was evaluated for cardiovascular events (death or hospitalization) and all-cause mortality.
resultsHeritability of QT dynamics during exercise and recovery were 10.7% and 5.4%, respectively. Genome-wide association studies identified 20 loci, of which 4 loci included genes implicated in mendelian long-QT syndrome. Five loci did not overlap with previously reported resting QT interval loci; candidate genes included
conclusionsQT interval dynamics during exercise and recovery are heritable markers but do not carry independent prognostic information for clinical outcomes in the UK Biobank, a population-based cohort. Their prognostic importance may relate to cardiovascular disease cohorts where structural heart disease or ischemia may influence repolarization dynamics. The strong overlap between QT dynamics and resting QT interval loci suggests common biological pathways; however, nonoverlapping loci suggests alternative mechanisms may exist that underlie QT interval dynamics.
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