Evidence map›Paper›PMID 32527175›Full record

ReviewJournal of neurogenetics

The discovery and consequences of the central role of the nervous system in the control of protein homeostasis.

Veena Prahlad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurogenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Veena PrahladDepartment of Biology, Aging Mind and Brain Initiative, University of Iowa, Iowa City, IA, USA.

Funding

Investigating how stress induced changes in maternal serotonin affect offspring development and stress resilienceR01MH126282 · NIMH · UNIVERSITY OF IOWA · PI Veena Prahlad · 2022 to 2026
$2.1M
Uncovering how serotonergic signaling non-autonomously regulates protein homeostasisR01AG050653 · NIA · UNIVERSITY OF IOWA · PI PRAHLAD, VEENA · 2016 to 2020
$1.5M
NIA NIH HHS R01 AG050653NIMH NIH HHS R01 MH126282
6 · The paper itself

Abstract

Organisms function despite wide fluctuations in their environment through the maintenance of homeostasis. At the cellular level, the maintenance of proteins as functional entities at target expression levels is called protein homeostasis (or proteostasis). Cells implement proteostasis through universal and conserved quality control mechanisms that surveil and monitor protein conformation. Recent studies that exploit the powerful ability to genetically manipulate specific neurons in

Indexed as

Nervous System Physiological PhenomenaAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsMammalsModels, AnimalModels, BiologicalNerve NetProteostasisCaenorhabditis elegans ProteinsC. elegansHomeostasisneuronalnon-autonomousproteostasis

Identifiers

PMID32527175
PMCPMC7736053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.