Evidence map›Paper›PMID 32527159›Full record

ArticleCirculation. Cardiovascular imaging2020

Event-Free Survival Following Successful Percutaneous Intervention in Acute Myocardial Infarction Depends on Microvascular Perfusion.

Feng Xie, Lijun Qian, Andrew Goldsweig, Di Xu, Thomas R Porter

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05760157 (To Establish a Multimodal Dynamic Risk Assessment System of Heart Failure in Patients With Myocardial Infarction Based on Coronary Microcirculation.), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05760157 unknown statusnot on this mapstarted 2023, after this paper: background citation

To Establish a Multimodal Dynamic Risk Assessment System of Heart Failure in Patients With Myocardial Infarction Based on Coronary Microcirculation.

TypeobservationalSponsorJian LiuRan2023 to 2025Enrolled567ConditionsHeart Failure, Acute Myocardial InfarctionArmsPossible risk factors of heart failure
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  7. Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024
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  16. Advances in Ultrasound Therapeutics.Current cardiology reports · 2021
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Feng Xie *Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE (F.X., A.G., T.R.P.).
Lijun Qian *Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (L.Q., D.X.).
Andrew GoldsweigDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE (F.X., A.G., T.R.P.).
Di XuDepartment of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (L.Q., D.X.).
Thomas R PorterDivision of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE (F.X., A.G., T.R.P.).
University of Nebraska Medical Center · USNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough small trials have detected microvascular obstruction (MVO) with variable frequency following restoration of epicardial blood flow, the independent impact of abnormal microvascular perfusion (MVP) in predicting patient outcome following emergent percutaneous coronary intervention in acute ST-segment-elevation myocardial infarction is unknown. The study aims to determine the impact of abnormal MVP following successful epicardial recanalization in ST-segment-elevation myocardial infarction.

methodsMVP was analyzed by low mechanical index ultrasound imaging within 48 hours of emergent percutaneous coronary intervention in 297 patients with acute ST-segment-elevation myocardial infarction who had restoration of Thrombolysis in Myocardial Infarction grade 3 flow in the infarct vessel. Patients were divided into normal segmental replenishment (normal MVP) after high mechanical index impulses versus delayed replenishment but normal plateau intensity (delayed MVP) and both delayed replenishment and reduced plateau intensity (MVO by definition). Demographic variables, left ventricular ejection fraction change, and 5-year follow-up of death, recurrent myocardial infarction, and congestive heart failure were analyzed.

resultsMVO was seen in 115 patients (39%), delayed MVP in 124 (42%), and normal MVP in 58 patients (19%). Patients with MVO had significant lower left ventricular ejection fraction change (39±12%) at hospital discharge compared with delayed MVP (50±10%;

conclusionsReduced or absent MVP following successful percutaneous coronary intervention in acute ST-segment-elevation myocardial infarction is common and associated with significantly worse outcome even with Thrombolysis in Myocardial Infarction 3 flow in the infarct vessel.

Indexed as

Coronary CirculationMicrocirculationPercutaneous Coronary InterventionAgedCoronary AngiographyDrug-Eluting StentsEchocardiographyElectrocardiographyFemaleHumansMaleMiddle AgedPatient DischargeProgression-Free SurvivalRecovery of FunctionRetrospective Studiesmyocardial infarctionpatient dischargepercutaneous coronary interventionST-segment–elevation myocardial infarctionultrasonography

Identifiers

PMID32527159
OpenAlexW3034744770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.