Evidence map›Paper›PMID 32527063›Full record

ArticleInternational journal of molecular sciences2020

Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases.

Yu-Lung Lin, Yi-Wei Lin, Jennifer Nhieu, Xiaoyin Zhang, Li-Na Wei

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Antisense oligonucleotide depletion ofmedRxiv : the preprint server for health sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. CRABP1-complexes in exosome secretion.Cell communication and signaling : CCS · 2024
    Article
  10. [Different concentrations of adapalene induce differentiation and apoptosis of SH-SY5Y cells].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yu-Lung LinDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Yi-Wei LinDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Jennifer NhieuDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Xiaoyin ZhangDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Li-Na WeiDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathwaysR01DK060521 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 2002 to 2022
$6.9M
TR2 NUCLEAR RECEPTOR IN VITAMIN A SIGNALING PATHWAYSR01DK054733 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WEI, LI-NA · 1999 to 2021
$5.7M
Non-canonical signaling of retinoic acid by Cellular Retinoic Acid Binding Protein 1F31DK123999 · NIDDK · UNIVERSITY OF MINNESOTA · PI NHIEU, JENNIFER · 2020 to 2023
$141k
National Institute of Health DK60521, DK54733NIDDK NIH HHS F31 DK123999NIDDK NIH HHS R01 DK054733NIDDK NIH HHS R01 DK060521
6 · The paper itself

Abstract

Cellular retinoic acid-binding protein 1 (CRABP1) is highly expressed in motor neurons. Degenerated motor neuron-like MN1 cells are engineered by introducing SOD

Indexed as

Amyotrophic Lateral SclerosisAnimalsCell DifferentiationData MiningDisease Models, AnimalEmbryonic Stem CellsGene Expression RegulationHedgehog ProteinsHumansMice, Inbred C57BLMotor NeuronsMuscular Atrophy, SpinalPromoter Regions, GeneticPyridinesPyrimidinesReceptors, Retinoic AcidGANT 61Gli1 protein, mouseHedgehog ProteinsPyridinesPyrimidinesReceptors, Retinoic Acidretinoic acid binding protein I, cellularShh protein, mouseZinc Finger Protein GLI1ALSchromatin remodelingCRABP1Glimotor neuronretinoic acidSMAsonic hedgehog

Identifiers

PMID32527063
PMCPMC7312406
OpenAlexW3035370106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.