Evidence map›Paper›PMID 32526967›Full record

ArticleInternational journal of molecular sciences2020

Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage.

Veronika S Georgieva, Julia Etich, Björn Bluhm, Mengjie Zhu, Christian Frie, Richard Wilson, Frank Zaucke, John Bateman, Bent Brachvogel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Veronika S GeorgievaDepartment of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
Julia EtichDr. Rolf M. Schwiete Research Unit for Osteoarthritis, Orthopaedic University Hospital Friedrichsheim, GmbH, 60528 Frankfurt, Germany.ORCID 0000-0003-3238-6692
Björn BluhmDepartment of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
Mengjie ZhuDepartment of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
Christian FrieDepartment of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
Richard WilsonCentral Science Laboratory, University of Tasmania, Hobart, TAS 7005, Australia.ORCID 0000-0003-0152-4394
Frank ZauckeDr. Rolf M. Schwiete Research Unit for Osteoarthritis, Orthopaedic University Hospital Friedrichsheim, GmbH, 60528 Frankfurt, Germany.ORCID 0000-0001-8542-0730
John BatemanMurdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0002-7680-9354
Bent BrachvogelDepartment of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
University of Cologne · DEOrthopaedic University Hospital Friedrichsheim · DEThe University of Melbourne · AUUniversity of Tasmania · AU

Funding

Deutsche Forschungsgemeinschaft BR2304/12-1Deutsche Forschungsgemeinschaft BR2304/7-1Deutsche Forschungsgemeinschaft FOR2722Horizon 2020 721432
6 · The paper itself

Abstract

MicroRNAs (miRNAs) regulate cartilage differentiation and contribute to the onset and progression of joint degeneration. These small RNA molecules may affect extracellular matrix organization (ECM) in cartilage, but for only a few miRNAs has this role been defined

Indexed as

AnimalsCartilage, ArticularCollagen Type IIExtracellular Matrix ProteinsGene Expression RegulationGrowth PlateMaleMatrix Metalloproteinase 13Mice, TransgenicMicroRNAsMultigene FamilyOsteoarthritisProteoglycan 4ProteoglycansSOX9 Transcription FactorSOXD Transcription FactorsCol2a1 protein, mouseCollagen Type IIExtracellular Matrix ProteinsMatrix Metalloproteinase 13MicroRNAsMmp13 protein, mousePrg4 protein, mouseProteoglycan 4ProteoglycansSox6 protein, mouseSox9 protein, mouseSOX9 Transcription FactorSOXD Transcription Factorsarticularcartilageextracellular matrixmiR-322miR-503Mirc24MMP13PRG4SOX6SOX9

Identifiers

PMID32526967
PMCPMC7312048
OpenAlexW3034541355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.