Evidence map›Paper›PMID 32526926›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Tiamulin-Resistant Mutants of the Thermophilic Bacterium

Erin E Killeavy, Gerwald Jogl, Steven T Gregory

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Hibernating ribosomes as drug targets?Frontiers in microbiology · 2024
    Review
  4. Review
  5. Article
  6. In Vitro and In Vivo Activity of 14-Molecules (Basel, Switzerland) · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Erin E KilleavyDepartment of Cell and Molecular Biology, The University of Rhode Island, Kingston, RI 02881, USA.
Gerwald JoglDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-5465-5315
Steven T GregoryDepartment of Cell and Molecular Biology, The University of Rhode Island, Kingston, RI 02881, USA.
University of Rhode Island · USBrown University · US

Funding

Structural Robustness of Ribosome Functional CentersR01GM094157 · NIGMS · BROWN UNIVERSITY · PI GREGORY, STEVEN, JOGL, GERWALD · 2010 to 2024
$4.4M
NIGMS NIH HHS R01 GM094157NIH HHS GM094157U.S. Department of Agriculture 1016013
6 · The paper itself

Abstract

Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the 50S ribosomal subunit A site and whose (((2-diethylamino)ethyl)thio)-acetic acid tail extends into the P site to interfere with peptide bond formation. We have isolated spontaneous tiamulin-resistant mutants of the thermophilic bacterium

Indexed as

antibiotic resistance mutationpeptidyltransferaseribosomal proteinribosomerRNAThermus thermophilustiamulin

Identifiers

PMID32526926
PMCPMC7345174
OpenAlexW3034636955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.