Evidence map›Paper›PMID 32526924›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study.

Federica Pezzuto, Gabriella Serio, Francesco Fortarezza, Anna Scattone, Concetta Caporusso, Alessandra Punzi, Domenica Cavone, Antonio Pennella, Andrea Marzullo, Luigi Vimercati

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Federica PezzutoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-8023-3108
Gabriella SerioPathology Division, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-9021-4560
Francesco FortarezzaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-8954-5888
Anna ScattonePathology Division, IRCCS National Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy.
Concetta CaporussoPathology Division, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Alessandra PunziPathology Division, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Domenica CavoneOccupational Health Division, Department of Interdisciplinary Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-2009-1806
Antonio PennellaPathology Division, Department of Surgery, University of Foggia, 71122 Foggia, Italy.
Andrea MarzulloPathology Division, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Luigi VimercatiOccupational Health Division, Department of Interdisciplinary Medicine, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-4072-2871
University of Bari Aldo Moro · ITUniversity of Padua · ITIstituto Tumori Bari · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with a poor survival. Although some advances in knowledge have been obtained for the pleural form, much less is known about DMPM. Advantages in terms of prognosis are still limited and strong efforts need to be made. The aim of our study was to correlate several histological and molecular factors with survival in a large cohort of 45 DMPMs. We evaluated histotype, nuclear grade, mitotic count, necrosis, inflammation, desmoplastic reaction, Ki67 percentage, WT-1 expression, p16 protein by immunohistochemistry and CDKN2A deletion by FISH. Our results showed that epithelioid histotype, nuclear grade 2, mitotic count ≤5 x mm

Indexed as

CDKN2Adiffuse malignant peritoneal mesotheliomaKi67p16prognostic factorsWT-1

Identifiers

PMID32526924
PMCPMC7345555
OpenAlexW3034434577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.