ArticleNature2020
The liver-brain-gut neural arc maintains the T
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.
0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 247 citations in OpenAlex.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Auricular Vagus Nerve Stimulation in Inflammatory Bowel Disease: Mechanistic Insights and Biomarker-Based Evaluation of Therapeutic Response.International journal of molecular sciences · 2026Review
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Gut-brain axis dysregulation in Parkinson's disease: Mechanisms linking microbiota to neuroinflammation and α-synuclein pathology.Journal of pharmaceutical analysis · 2026Review
- Electroacupuncture Attenuates Cerebral Ischemia-Reperfusion Injury via Vagus Nerve-α7 Nicotinic Acetylcholine Receptor-Dependent Microglial Polarization.Journal of the American Heart Association · 2026Article
- A Non-spinal Neural Circuit for Transmitting Information of Bladder Conditions.Neuroscience bulletin · 2026Article
- Vagus nerve as the hub in peripheral immune-inflammatory response: implications for related therapeutic drugs.Molecular biology reports · 2026Review
- Rotavirus mucosal immunology: insights and research priorities from an international convening in Liverpool, March 2024.NPJ vaccines · 2026Article
- Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities.Journal of diabetes and metabolic disorders · 2026Review
- Efficacy of Japanese Maca Powder Against Aging Stress in Human Dermal Fibroblasts.International journal of molecular sciences · 2026Article
- Neuro-immune interactions in gastrointestinal oncology: Mechanisms, challenges, and therapeutic potential.Innovation (Cambridge (Mass.)) · 2026Review
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer.Signal transduction and targeted therapy · 2026Review
- Abdominal ultrasound activates afferent vagus nerve fibers and induces anti-inflammatory effects.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The gut-liver axis modulates intestinal immune homeostasis.Mucosal immunology · 2026Review
- Mechanistic insights into the liver-brain axis during chronic liver disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Gut Microbiota and Interorgan Communication Among the Gut, Brain, and Beyond.Internal medicine (Tokyo, Japan) · 2026Review
- I-FABP, citrulline and non-invasive liver dysfunction indices in patients with depression - cross-sectional study results.BMC gastroenterology · 2026Article
- The liver-brain axis, from its function to preventive therapeutic strategies in diseases.Frontiers in endocrinology · 2026Review
93 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 8 institutions in 1 country.
Toshiaki TerataniDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Yohei MikamiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. yoheimikami@keio.jp.ORCID http://orcid.org/0000-0001-5104-4415
Nobuhiro NakamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5203-7444
Takahiro SuzukiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Yosuke HaradaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Koji OkabayashiDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Yuya HagiharaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0721-2850
Nobuhito TanikiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Keita KohnoDepartment of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Shinsuke ShibataDepartment of Physiology, Keio University School of Medicine, Tokyo, Japan.
Kentaro MiyamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Harumichi IshigameLaboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Po-Sung ChuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Tomohisa SujinoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Wataru SudaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Masahira HattoriRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Minoru MatsuiAozora Asakusa Clinic, Tokyo, Japan.
Takaharu OkadaLaboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-4784-5145
Hideyuki OkanoDepartment of Physiology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7482-5935
Masayuki InoueGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3274-551X
Toshihiko YadaCenter for Integrative Physiology, Kansai Electric Power Medical Research Institute, Kobe Biotechnology Research and Human Resource Development Center, Kobe, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Akihiko YoshimuraDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Mamoru TanidaDepartment of Physiology II, Kanazawa Medical University, Uchinada, Japan.
Makoto TsudaDepartment of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yusaku IwasakiGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. takagast@z2.keio.jp.
Keio University · JPRIKEN Center for Integrative Medical Sciences · JPKyushu University · JPKanazawa Medical University · JPKansai Electric Power (Japan) · JPKyoto Prefectural University · JPThe University of Tokyo · JPWaseda University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent clinical and experimental evidence has evoked the concept of the gut-brain axis to explain mutual interactions between the central nervous system and gut microbiota that are closely associated with the bidirectional effects of inflammatory bowel disease and central nervous system disorders
Indexed as
Afferent PathwaysAnimalsAntigen-Presenting CellsBrainColitisHomeostasisHumansIntestinesLiverMaleMiceNeuronsRatsReceptors, MuscarinicSpleenT-Lymphocytes, RegulatoryReceptors, Muscarinic
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.