Evidence map›Paper›PMID 32526386›Full record

ArticleNeuroImage2020

FastSurfer - A fast and accurate deep learning based neuroimaging pipeline.

Leonie Henschel, Sailesh Conjeti, Santiago Estrada, Kersten Diers, Bruce Fischl, Martin Reuter

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 328 papers.

0numbers the graph read from it
0cells of the map it votes in
328citing papers in PubMed
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

328 citing papers in PubMed, 618 citations in OpenAlex.

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  18. Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  20. Article

268 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Leonie HenschelGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Sailesh ConjetiGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Santiago EstradaGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Kersten DiersGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Bruce FischlA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA.
Martin ReuterGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA. Electronic address: martin.reuter@dzne.de.
German Center for Neurodegenerative Diseases · DEHarvard University · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORKU24RR021382 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2008
$24.1M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
VCID Biomarkers Coordinating CenterU24NS100591 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg · 2016 to 2026
$19.8M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NCRR NIH HHS U24 RR021382NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066546NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG021910NIA NIH HHS R01 AG064027NIA NIH HHS R56 AG064027NIA NIH HHS U01 AG024904NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB006758NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R21 EB018907NIDDK NIH HHS R21 DK108277NIMH NIH HHS P50 MH071616NIMH NIH HHS U01 MH093765NIMH NIH HHS U01 MH117023NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS052585NINDS NIH HHS R01 NS070963NINDS NIH HHS R01 NS083534NINDS NIH HHS R01 NS105820NINDS NIH HHS R21 NS072652NINDS NIH HHS RF1 NS115268NINDS NIH HHS U01 NS086625NINDS NIH HHS U24 NS100591NLM NIH HHS R01 LM012719
6 · The paper itself

Abstract

Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose a fast and accurate deep learning based neuroimaging pipeline for the automated processing of structural human brain MRI scans, replicating FreeSurfer's anatomical segmentation including surface reconstruction and cortical parcellation. To this end, we introduce an advanced deep learning architecture capable of whole-brain segmentation into 95 classes. The network architecture incorporates local and global competition via competitive dense blocks and competitive skip pathways, as well as multi-slice information aggregation that specifically tailor network performance towards accurate segmentation of both cortical and subcortical structures. Further, we perform fast cortical surface reconstruction and thickness analysis by introducing a spectral spherical embedding and by directly mapping the cortical labels from the image to the surface. This approach provides a full FreeSurfer alternative for volumetric analysis (in under 1 ​min) and surface-based thickness analysis (within only around 1 ​h runtime). For sustainability of this approach we perform extensive validation: we assert high segmentation accuracy on several unseen datasets, measure generalizability and demonstrate increased test-retest reliability, and high sensitivity to group differences in dementia.

Indexed as

Deep LearningBrainHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeuroimagingReproducibility of ResultsSoftwareArtificial intelligenceComputational neuroimagingDeep learningFreesurferStructural MRI

Identifiers

PMID32526386
PMCPMC7898243
OpenAlexW3033878890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.