Evidence map›Paper›PMID 32526384›Full record

ArticleNeuroImage2020

Non-invasive measurement of biochemical profiles in the healthy fetal brain.

Subechhya Pradhan, Kushal Kapse, Marni Jacobs, Nickie Niforatos-Andescavage, Jessica Lynn Quistorff, Catherine Lopez, Kathryn Lee Bannantine, Nicole Reinholdt Andersen, Gilbert Vezina, Catherine Limperopoulos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Methodological comparison of fetal brainExperimental physiology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
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  9. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Subechhya PradhanCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA; Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, 20010, USA; Department of Radiology, The George Washington University School of Medicine, Washington, DC, 20052, USA; Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, 20052, USA.
Kushal KapseCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA.
Marni JacobsDepartment of Biostatistics and Study Methodology, Children's Research Institute, Children's National Hospital, Washington, DC, 20010, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, CA, 92093, USA.
Nickie Niforatos-AndescavageCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA; Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, 20052, USA; Division of Neonatology, Children's National Hospital, Washington, DC, 20010, USA.
Jessica Lynn QuistorffCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA.
Catherine LopezCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA.
Kathryn Lee BannantineCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA.
Nicole Reinholdt AndersenCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA.
Gilbert VezinaDepartment of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, 20010, USA.
Catherine LimperopoulosCenter for the Developing Brain, Children's National Hospital, Washington, DC, 20010, USA; Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, 20010, USA; Department of Radiology, The George Washington University School of Medicine, Washington, DC, 20052, USA; Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, 20052, USA. Electronic address: climpero@childrensnational.org.
Children's National · USGeorge Washington University Hospital · US

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI JAISWAL, JYOTI K · 2016 to 2020
$5.9M
Antecedents of Impaired Brain Development in Fetuses with Heart DiseaseR01HL116585 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LIMPEROPOULOS, CATHERINE · 2013 to 2017
$3.8M
CIHR MOP-81116NHLBI NIH HHS R01 HL116585NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Proton magnetic resonance spectroscopy (

objectiveTo investigate the normative trajectory of the fetal brain metabolites during the second half of gestation, and to determine the impact of using different Cramer-Rao Lower Bounds (CRLB) threshold on metabolite measurements using magnetic resonance spectroscopy. STUDY

designWe prospectively enrolled 219 pregnant women with normal fetal ultrasound and biometric measures. We performed a total of 331 fetal

resultsWe successfully acquired and analyzed fetal

conclusionWe report serial fetal brain biochemical profiles in a large cohort of health fetuses studied twice in gestation with a high success rate in the second and third trimester of pregnancy. We present normative in-vivo fetal brain metabolite trajectories over a 21-week gestational period which can be used to non-invasively measure and monitor brain biochemistry in the healthy and high-risk fetus.

Indexed as

AdultAspartic AcidBrainCholineCreatineFemaleFetal DevelopmentGestational AgeHumansMagnetic Resonance ImagingPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesProton Magnetic Resonance SpectroscopyReference ValuesAspartic AcidCholineCreatineCRLBFetal brainMagnetic resonance spectroscopyMetabolitesMetabolite trajectoryNormative

Identifiers

PMID32526384
PMCPMC7491254
OpenAlexW3033467156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.