Evidence map›Paper›PMID 32525980›Full record

ArticleThe Journal of infectious diseases2020

Addressing Ethical Challenges in US-Based HIV Phylogenetic Research.

Liza Dawson, Nanette Benbow, Faith E Fletcher, Seble Kassaye, Amy Killelea, Stephen R Latham, Lisa M Lee, Thomas Leitner, Susan J Little, Sanjay R Mehta and 8 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) from pre and asymptomatic infected individuals: a systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Tracking HIV Through Wastewater: Ethical Considerations in Public Health Surveillance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Molecular HIV Surveillance: Beyond Cluster Detection and Response.AIDS research and human retroviruses · 2025
    Article
  12. Action needed to address molecular HIV surveillance ethical concerns.Canadian journal of public health = Revue canadienne de sante publique · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Liza DawsonWalter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Nanette BenbowFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Faith E FletcherSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Seble KassayeGeorgetown University Medical Center, Washington, District of Columbia, USA.
Amy KilleleaNational Alliance of State and Territorial AIDS Directors, Washington, District of Columbia, USA.
Stephen R LathamYale Interdisciplinary Center for Bioethics, New Haven, Connecticut, USA.
Lisa M LeeVirginia Tech, Blacksburg, Virginia, USA.
Thomas LeitnerLos Alamos National Laboratory, Los Alamos, New Mexico, USA.
Susan J LittleUniversity of California at San Diego, San Diego, California, USA.
Sanjay R MehtaUniversity of California at San Diego, San Diego, California, USA.
Omar MartinezTemple University, Philadelphia, Pennsylvania, USA.
Brian MinalgaFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Art PoonUniversity of Western Ontario, London, Ontario, Canada.
Stuart RennieUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Jeremy SugarmanJohns Hopkins University, Baltimore, Maryland, USA.
Patricia SweeneyCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Lucia V TorianNew York City Department of Health, New York, New York, USA.
Joel O WertheimUniversity of California at San Diego, San Diego, California, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
Leveraging public health genotyping databases for near real-time HIV surveillanceR01AI135946 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI LEITNER, THOMAS K. · 2019 to 2023
$4.2M
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI087520NIAID NIH HHS R01 AI135946
6 · The paper itself

Abstract

In recent years, phylogenetic analysis of HIV sequence data has been used in research studies to investigate transmission patterns between individuals and groups, including analysis of data from HIV prevention clinical trials, in molecular epidemiology, and in public health surveillance programs. Phylogenetic analysis can provide valuable information to inform HIV prevention efforts, but it also has risks, including stigma and marginalization of groups, or potential identification of HIV transmission between individuals. In response to these concerns, an interdisciplinary working group was assembled to address ethical challenges in US-based HIV phylogenetic research. The working group developed recommendations regarding (1) study design; (2) data security, access, and sharing; (3) legal issues; (4) community engagement; and (5) communication and dissemination. The working group also identified areas for future research and scholarship to promote ethical conduct of HIV phylogenetic research.

Indexed as

PhylogenyAdvisory CommitteesBiomedical ResearchCommunity ParticipationComputer SecurityConfidentialityHIVHIV InfectionsHumansInformation DisseminationNational Institutes of Health (U.S.)Public Health SurveillanceResearch DesignUnited StatesethicsHIV/AIDSphylogeneticspublic health

Identifiers

PMID32525980
PMCPMC7661760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.