Evidence map›Paper›PMID 32525964›Full record

ArticlePloS one2020

The role of diabetes in cardiomyopathies of different etiologies-Characteristics and 1-year follow-up results of the EVITA-HF registry.

Christine Meindl, Matthias Hochadel, Lutz Frankenstein, Oliver Bruder, Matthias Pauschinger, Rainer Hambrecht, Wolfgang von Scheidt, Otmar Pfister, Andreas Hartmann, Lars S Maier and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

Christine MeindlDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.ORCID 0000-0001-7086-0469
Matthias HochadelStiftung Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany.
Lutz FrankensteinDepartment of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.
Oliver BruderDepartment of Cardiology and Angiology, Elisabeth-Hospital Essen, Essen, Germany.
Matthias PauschingerDepartment of Internal Medicine 8, Nürnberg Hospital, Nürnberg, Germany.
Rainer HambrechtDepartment of Internal Medicine II, Hospital Links der Weser, Bremen, Germany.
Wolfgang von ScheidtDepartment of Internal Medicine I, University Hospital Augsburg, Augsburg, Germany.
Otmar PfisterDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Andreas HartmannDepartment of Cardiology and Internal Intensive Care, St. Georg Hospital Leipzig, Leipzig, Germany.
Lars S MaierDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Jochen SengesStiftung Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany.
Bernhard UnsöldDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
University Hospital Regensburg · DEStiftung Institut für Herzinfarktforschung · DEElisabeth-Krankenhaus Essen · DEHeidelberg University · DEKlinikum Links der Weser · DEKlinikum St. Georg · DENuremberg Hospital · DEUniversity Hospital Augsburg · DEUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes is a major risk factor for cardiovascular diseases, e.g. coronary artery disease (CAD). But it has also been shown that diabetes can cause heart failure independently of ischemic heart disease (IHD) by causing diabetic cardiomyopathy. In contrast to diabetes and IHD, limited data exist regarding patients with diabetes and dilated cardiomyopathy (DCM).

methodsEVIdence based TreAtment in Heart Failure (EVITA-HF) comprises web-based case report data on demography, diagnostic measures, adverse events and 1-year follow-up of patients hospitalized for chronic heart failure and an ejection fraction ≤40%. In the present study we focused on the results of patients with diabetes and heart failure.

resultsBetween February 2009 and November 2015, 4101 patients with chronic heart failure were included in 16 tertiary care centers in Germany. The mortality in patients with diabetes and DCM (n = 323) was more than double (15.2%) than that of DCM patients without diabetes (6.5%, p<0.001, n = 885). In contrast the mortality rate of patients with IHD was not influenced by the presence of diabetes (17.6% in patients with IHD and diabetes n = 945, vs. 14.7% in patients with IHD and no diabetes, n = 1236, p = 0.061). The results also remained stable after performing a multivariable analysis (unadjusted p-value for interaction = 0.002, adjusted p = 0.046).

conclusionThe influence of diabetes on the mortality rate is only significant in patients with DCM not in patients with CAD. Therefore, the underlying mechanisms of this effect should be studied in greater detail to improve patient care and outcome.

Indexed as

AgedCardiomyopathy, DilatedDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedRegistries

Identifiers

PMID32525964
PMCPMC7289353
OpenAlexW3034347219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.