ReviewPLoS neglected tropical diseases2020
A comparative analysis of the 2007 and 2017 Italian chikungunya outbreaks and implication for public health response.
Review in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- A real-time mechanistic framework for early inference of chikungunya transmission and outbreak sizes in mainland France, 2025.PLoS neglected tropical diseases · 2026Article
- Lessons learned exploiting a multi-year large-scale data set derived from operational quality assessment of mosquito larval treatments in rain catch basins.Pest management science · 2025Article
- Cross-sectional entomological data reveals an increased risk of arboviral transmission in a year of record-breaking heat in Southern Europe.Communications medicine · 2025Article
- Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa.Parasite (Paris, France) · 2025Article
- Strategic vaccination responses to Chikungunya outbreaks in Rome: Insights from a dynamic transmission model.PLoS neglected tropical diseases · 2024Article
- An easier life to come for mosquito researchers: field-testing across Italy supports VECTRACK system for automatic counting, identification and absolute density estimation of Aedes albopictus and Culex pipiens adults.Parasites & vectors · 2024Article
- Vaccine value profile for Chikungunya.Vaccine · 2024Article
- Arthropod-Borne Viruses of Human and Animal Importance: Overwintering in Temperate Regions of Europe during an Era of Climate Change.Microorganisms · 2024Review
- Chikungunya virus vaccine: a decade of progress solving epidemiological dilemma, emerging concepts, and immunological interventions.Frontiers in microbiology · 2024Review
- Reporting delays of chikungunya cases during the 2017 outbreak in Lazio region, Italy.PLoS neglected tropical diseases · 2023Article
- How habitat factors affect an Aedes mosquitoes driven outbreak at temperate latitudes: The case of the Chikungunya virus in Italy.PLoS neglected tropical diseases · 2023Article
- Impact of climate change on vector- and rodent-borne infectious diseases.Journal of health monitoring · 2023Article
- Mosquito-borne viruses causing human disease in Fennoscandia-Past, current, and future perspectives.Frontiers in medicine · 2023Review
- Mosquito alert: leveraging citizen science to create a GBIF mosquito occurrence dataset.GigaByte (Hong Kong, China) · 2022Article
- AIMSurv: First pan-European harmonized surveillance ofGigaByte (Hong Kong, China) · 2022Article
- Molecular and biological characterization of an Asian-American isolate of Chikungunya virus.PloS one · 2022Article
- An unwanted companion reaches the country: the first record of the alien mosquito Aedes japonicus japonicus (Theobald, 1901) in Slovakia.Parasites & vectors · 2021Article
- Flavivirus Persistence in Wildlife Populations.Viruses · 2021Review
- Potential for online crowdsourced biological recording data to complement surveillance for arthropod vectors.PloS one · 2021Article
- Spatio-Temporal Distribution of Aedes Albopictus and Culex Pipiens along an Urban-Natural Gradient in the Ventotene Island, Italy.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KEY
resultsBoth outbreaks started in small towns, but cases were also detected in nearby larger cities where transmission was limited to small clusters. The time spans between the first and the last symptom onsets were similar between the 2 outbreaks, and the delay from the symptom onset of the index case and the first case notified was considerable. Comparable infection and transmission rates were observed in laboratory. The basic reproductive number (R0) was estimated in the range of 1.8-6 (2007) and 1.5-2.6 (2017). Clinical characteristics were similar between outbreaks, and no acute complications were reported, though a higher frequency of ocular symptoms, myalgia, and rash was observed in 2017. Very little is known about the immune mediator profile of CHIKV-infected patients during the 2 outbreaks. Regarding public health responses, after the 2007 outbreak, the Italian Ministry of Health developed national guidelines to implement surveillance and good practices to prevent and control autochthonous transmission. However, only a few regional authorities implemented it, and the perception of outbreak risk and knowledge of clinical symptoms and transmission dynamics by general practitioners remained low. MAJOR
conclusionsEfforts should be devoted to developing suitable procedures for early detection of virus circulation in the population, possibly through the analysis of medical records in near real time. Increasing the awareness of CHIKV of general practitioners and public health officials through tailored education may be effective, especially in small coastal towns where the outbreak risk may be higher. A key element is also the shift of citizen awareness from considering Aedes mosquitoes not only as a nuisance problem but also as a public health one. We advocate the need of strengthening the surveillance and of promoting the active participation of the communities to prevent and contain future outbreaks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.