Evidence map›Paper›PMID 32525804›Full record

ArticleeLife2020

FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction.

Avantika Gupta, Hugo Stocker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Laser capture microdissection.Nature reviews. Methods primers · 2025
    Article
  3. The Role of Forkhead Box O in Pathogenesis and Therapy of Diabetes Mellitus.International journal of molecular sciences · 2022
    Review
  4. Review
  5. A coherent FOXO3-SNAI2 feed-forward loop in autophagy.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Avantika GuptaInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-8170-6720
Hugo StockerInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-4142-1464

Funding

Krebsliga Schweiz KLS-3407-02-2014Novartis Stiftung für Medizinisch-Biologische Forschung 18C162Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung SNF 31003A_166680
6 · The paper itself

Abstract

The transcription factor FoxO has been shown to block proliferation and progression in mTORC1-driven tumorigenesis but the picture of the relevant FoxO target genes remains incomplete. Here, we employed RNA-seq profiling on single clones isolated using laser capture microdissection from

Indexed as

Drosophila ProteinsForkhead Transcription FactorsAnimalsCaloric RestrictionDrosophilaEndoplasmic ReticulumEndoplasmic Reticulum StressFemaleGene Knockdown TechniquesImaginal DiscsLarvaOrgan SpecificityTranscriptomeDrosophila ProteinsForkhead Transcription FactorsFOXO protein, DrosophilaTSC1 protein, Drosophilacancer biologyD. melanogasterER stressFoxOgeneticsgenomicslaser capture microdissectionTsc1

Identifiers

PMID32525804
PMCPMC7289595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.