Evidence map›Paper›PMID 32525743›Full record

ArticleCirculation. Genomic and precision medicine2020

Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality.

Jiantao Ma, Casey M Rebholz, Kim V E Braun, Lindsay M Reynolds, Stella Aslibekyan, Rui Xia, Niranjan G Biligowda, Tianxiao Huan, Chunyu Liu, Michael M Mendelson and 40 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  10. Ketogenic diet, cardiometabolic diseases and aging.Journal of geriatric cardiology : JGC · 2026
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  12. Review
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  17. Nutrition as a systems regulator of brain aging trajectories.Frontiers in molecular neuroscience · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

50 authors at 20 institutions in 7 countries.

Jiantao Ma *Nutrition Epidemiology & Data Science, Friedman School of Nutrition Science and Policy (J.M.), USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Casey M Rebholz *Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (C.M.R., E.A.H.).
Kim V E Braun *Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (C.M.R., E.A.H.).
Lindsay M Reynolds *Department of Epidemiology & Prevention (L.M.R., M.Z.V., Y.L.), Wake Forest School of Medicine, Winston-Salem, NC.
Stella Aslibekyan *Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (S.A., N.G.B.).
Rui XiaInstitute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX (R.X., M.F.).
Niranjan G BiligowdaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (S.A., N.G.B.).
Tianxiao HuanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD & the Framingham Heart Study, Framingham, MA (J.M., T.H., C.L., M.M.M., R.J., D.L.).
Chunyu LiuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD & the Framingham Heart Study, Framingham, MA (J.M., T.H., C.L., M.M.M., R.J., D.L.).
Michael M MendelsonDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA (M.M.M.).
Roby JoehanesPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD & the Framingham Heart Study, Framingham, MA (J.M., T.H., C.L., M.M.M., R.J., D.L.).
Emily A HuDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (C.M.R., E.A.H.).
Mara Z VitolinsDepartment of Epidemiology & Prevention (L.M.R., M.Z.V., Y.L.), Wake Forest School of Medicine, Winston-Salem, NC.
Alexis C WoodUSDA/ARS Children's Nutrition Rsrch Center, Baylor College of Medicine, Houston, TX (A.C.W.).
Kurt LohmanDepartment of Biostatistics (K.L.), Wake Forest School of Medicine, Winston-Salem, NC.
Carolina Ochoa-RosalesDepartment of Epidemiology (K.V.E.B., C.O.-R., T.V.).
Joyce van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands (J.v.M., A.U.).
Andre UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands (J.v.M., A.U.).
Yongmei LiuDepartment of Epidemiology & Prevention (L.M.R., M.Z.V., Y.L.), Wake Forest School of Medicine, Winston-Salem, NC.
Mohamed A ElhadadInstitute of Epidemiology (M.A.E., M.H., M.W., A.P.), Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany.
Margit HeierKORA Study Centre, University Hospital of Augsburg, Augsburg, Germany (M.H.).
Melanie WaldenbergerInstitute of Epidemiology (M.A.E., M.H., M.W., A.P.), Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany.
Annette PetersInstitute of Epidemiology (M.A.E., M.H., M.W., A.P.), Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany.
Elena ColicinoDepartment of Environmental Health Sciences, Columbia University, New York City, NY (E.C.).
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health (E.A.W., A.B.), School of Medicine, University of North Carolina, Chapel Hill, NC.
Antoine BaldassariDepartment of Epidemiology, Gillings School of Global Public Health (E.A.W., A.B.), School of Medicine, University of North Carolina, Chapel Hill, NC.
Sina A GharibThe Cardiovascular Health Research Unit, University of Washington, Seattle, WA (S.A.G., N.S., J.A.B., C.M.S.).
Nona SotoodehniaThe Cardiovascular Health Research Unit, University of Washington, Seattle, WA (S.A.G., N.S., J.A.B., C.M.S.).
Jennifer A BrodyThe Cardiovascular Health Research Unit, University of Washington, Seattle, WA (S.A.G., N.S., J.A.B., C.M.S.).
Colleen M SitlaniThe Cardiovascular Health Research Unit, University of Washington, Seattle, WA (S.A.G., N.S., J.A.B., C.M.S.).
Toshiko TanakaLongitudinal Study Section, Nat Institute of Aging, NIH, Bethesda, MD (T.T.).
W David HillLothian Birth Cohorts (W.D.H., J.C., I.J.D.), University of Edinburgh, Edinburgh, United Kingdom.
Janie CorleyLothian Birth Cohorts (W.D.H., J.C., I.J.D.), University of Edinburgh, Edinburgh, United Kingdom.
Ian J DearyLothian Birth Cohorts (W.D.H., J.C., I.J.D.), University of Edinburgh, Edinburgh, United Kingdom.
Yan ZhangDivision of Clinical Epidemiology & Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (Y. Zhang, B.S., H.B.).
Ben SchöttkerDivision of Clinical Epidemiology & Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (Y. Zhang, B.S., H.B.).
Hermann BrennerDivision of Clinical Epidemiology & Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (Y. Zhang, B.S., H.B.).
Maura E WalkerSection of Preventive Medicine & Epidemiology, Boston University School of Medicine, MA (M.E.W.).
Shumao YeCardiovascular Nutrition Laboratory (S.Y., A.H.L.), USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Steve NguyenDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (S.N., J.P., E.W.D.).
Jim PankowDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (S.N., J.P., E.W.D.).
Ellen W DemerathDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (S.N., J.P., E.W.D.).
Yinan ZhengCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center & Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y. Zheng, L.H.).
Lifang HouCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center & Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y. Zheng, L.H.).
Liming LiangDepartment of Epidemiology (L.L., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA.
Alice H LichtensteinCardiovascular Nutrition Laboratory (S.Y., A.H.L.), USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Frank B HuDepartment of Epidemiology (L.L., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA.
Myriam FornageInstitute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX (R.X., M.F.).
Trudy VoortmanDepartment of Epidemiology (K.V.E.B., C.O.-R., T.V.).
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD & the Framingham Heart Study, Framingham, MA (J.M., T.H., C.L., M.M.M., R.J., D.L.).
Wake Forest University · USWashington State Department of Health · USFramingham Heart Study · USGerman Cancer Research Center · DEHelmholtz Zentrum München · DEJohns Hopkins University · USNHS Lothian · GBTufts University · USUniversity of Minnesota · USBoston University · USErasmus MC · NLHarvard University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityThe University of Texas Health Science Center at Houston · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USBoston Children's Hospital · USChildren's Nutrition Research Center at Baylor College of Medicine · USCity University of New York · USNational Institute on Aging · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Medical Research Council G0700704Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL136700NHLBI NIH HHS K08 HL116640NHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01 HL101250NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL104135NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL007024NHLBI NIH HHS T32 HL125232NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS HHSN271201100004CNIA NIH HHS R01 AG023629NIA NIH HHS R03 AG056959NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK063491NIEHS NIH HHS R01 ES020836WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundDNA methylation patterns associated with habitual diet have not been well studied.

methodsDiet quality was characterized using a Mediterranean-style diet score and the Alternative Healthy Eating Index score. We conducted ethnicity-specific and trans-ethnic epigenome-wide association analyses for diet quality and leukocyte-derived DNA methylation at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts including 6662 European ancestry, 2702 African ancestry, and 360 Hispanic ancestry participants. For diet-associated CpGs identified in epigenome-wide analyses, we conducted Mendelian randomization (MR) analysis to examine their relations to cardiovascular disease risk factors and examined their longitudinal associations with all-cause mortality.

resultsWe identified 30 CpGs associated with either Mediterranean-style diet score or Alternative Healthy Eating Index, or both, in European ancestry participants. Among these CpGs, 12 CpGs were significantly associated with all-cause mortality (Bonferroni corrected

conclusionsHabitual diet quality was associated with differential peripheral leukocyte DNA methylation levels of 30 CpGs, most of which were also associated with multiple health outcomes, in European ancestry individuals. These findings demonstrate that integrative genomic analysis of dietary information may reveal molecular targets for disease prevention and treatment.

Indexed as

Diet, MediterraneanDNA MethylationBody Mass IndexCardiovascular DiseasesCpG IslandsFatty Acid DesaturasesGenome-Wide Association StudyHumansLeukocytesNuclear ProteinsRisk FactorsSuppressor of Cytokine Signaling 3 ProteinTriglyceridesWhite PeopleFADS2 protein, humanFatty Acid DesaturasesNAP1L4 protein, humanNuclear ProteinsSOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteinTriglyceridescardiovascular diseasedietDNA methylationepigenometriglycerides

Identifiers

PMID32525743
PMCPMC7442697
OpenAlexW3034909441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.