ArticleImmunity, inflammation and disease2020
Humanized mouse model: Hematopoietic stemcell transplantation and tracking using short tandem repeat technology.
Article in Immunity, inflammation and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- "Next-Generation Cord Blood Expansion: Bridging the Cell Dose Gap with Bioengineered Niches and Clinical Breakthroughs".Stem cell reviews and reports · 2026Review
- Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts.JHEP reports : innovation in hepatology · 2025Article
- Inhibition of caspase pathways limits CD4Retrovirology · 2024Article
- Virus-Based Immuno-Oncology Models.Biomedicines · 2022Review
- A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies.Stem cells translational medicine · 2021Article
- Preclinical platform for long-term evaluation of immuno-oncology drugs using hCD34+ humanized mouse model.Journal for immunotherapy of cancer · 2020Article
- Humanized mouse model: Hematopoietic stemcell transplantation and tracking using short tandem repeat technology.Immunity, inflammation and disease · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionModels of mice carrying a human immune system, so-called humanized mice, are used increasingly as preclinical models to bridge the gap between model organisms and human beings. Challenges of the humanized mouse model include finding suitable sources for human hematopoietic stem cells (HSC) and reaching sufficient engraftment of these cells in immunocompromised mice.
methodsIn this study, we compared the use of CD34
resultsIt was found that, in vitro, CB-derived and adult HSC show comparable purity, viability, and differentiation potential in colony-forming unit assays. However, in vivo, CB-derived HSC engrafted to a significantly higher extent in NOD.Cg-Prkdc
conclusionFrom these findings, we conclude that adult mobilized HSC are less suitable for generating a humanized immune system in mice than CB-derived cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.