ArticleAngewandte Chemie (International ed. in English)2020
Selective Monofunctionalization Enabled by Reaction-History-Dependent Communication in Catalytic Rotaxanes.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Spotlight on Mechanosterics: A Bulky Macrocycle Promotes Functional Group Reactivity in a [2]Rotaxane.Journal of the American Chemical Society · 2025Article
- Kinetically controlled synthesis of rotaxane geometric isomers.Chemical science · 2024Article
- A light-gated regulation of the reaction site by a cucurbit[7]uril macrocycle.Chemical science · 2022Article
- Iterative Exponential Growth of Oxygen-Linked Aromatic Polymers Driven by Nucleophilic Aromatic Substitution Reactions.Frontiers in chemistry · 2021Article
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8 authors.
Funding
Abstract
Selective monofunctionalization of substrates with distant, yet equally reactive functional groups is difficult to achieve, as it requires the second functional group to selectively modulate its reactivity once the first functional group has reacted. We now show that mechanically interlocked catalytic rings can effectively regulate the reactivity of stoppering groups in rotaxanes over a distance of about 2 nm. Our mechanism of communication is enabled by a unique interlocked design, which effectively removes the catalytic rings from the substrates by fast dethreading as soon as the first reaction has taken place. Our method not only led to a rare example of selective monofunctionalization, but also to a "molecular if function". Overall, the study presents a way to get distant functional groups to communicate with each other in a reaction-history-dependent manner by creating linkers that can ultimately perform logical operations at the molecular level.
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