ArticleThe EMBO journal2020
CCR5 deficiency impairs CD4
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Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications.Biomedicines · 2025Review
- Regulation of CD4 + T cell differentiation and function by glucose metabolism.Genes and immunity · 2025Review
- Ceramide signaling in immunity: a molecular perspective.Lipids in health and disease · 2025Review
- Emerging biochemical, microbial and immunological evidence in the search for why HLA-BCell chemical biology · 2025Review
- Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target.Frontiers in immunology · 2025Article
- Single-cell sequencing reveals the immune landscape of breast cancer patients with brain metastasis.Thoracic cancer · 2024Article
- Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation.Journal of neuroinflammation · 2024Article
- Functional roles of sphingolipids in immunity and their implication in disease.Experimental & molecular medicine · 2023Review
- Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection.European journal of medical research · 2022Article
- A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19.European journal of medical research · 2021Observational
- Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity.International immunopharmacology · 2021Article
- Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells.International journal of molecular sciences · 2021Article
- Exhausted and Apoptotic BALF T Cells in Proinflammatory Airway Milieu at Acute Phase of Severe Mycoplasma Pneumoniae Pneumonia in Children.Frontiers in immunology · 2021Article
- CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population.Frontiers in immunology · 2021Review
- The Chemokine Receptor CCR5 Links Memory CD4Frontiers in immunology · 2021Article
- CCR5 deficiency impairs CD4The EMBO journal · 2020Article
- CCR5 deficiency/CCR5Δ32: resistant to HIV infection at the cost of curtailed CD4The EMBO journal · 2020Article
- Ceramide Pathway Regulators Predict Clinical Prognostic Risk and Affect the Tumor Immune Microenvironment in Lung Adenocarcinoma.Frontiers in oncology · 2020Article
- Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 2 countries.
Ana Martín-Leal *Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB/CSIC), Madrid, Spain.
Raquel Blanco *Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB/CSIC), Madrid, Spain.
Josefina CasasDepartment of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
María E SáezCentro Andaluz de Estudios Bioinformáticos (CAEBi), Seville, Spain.
Elena Rodríguez-BovolentaDepartment of Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa (CBMSO/CSIC), Madrid, Spain.
Itziar de RojasAlzheimer Research Center, Memory Clinic of the Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Carina DrechslerSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Luis Miguel RealUnit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain.
Gemma FabriasDepartment of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
Agustín RuízAlzheimer Research Center, Memory Clinic of the Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Mario CastroInterdisciplinary Group of Complex Systems, Escuela Técnica Superior de Ingeniería, Universidad Pontificia Comillas, Madrid, Spain.ORCID 0000-0003-3288-6144
Wolfgang Wa SchamelSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-4496-3100
Balbino AlarcónDepartment of Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa (CBMSO/CSIC), Madrid, Spain.ORCID 0000-0001-7820-1070
Hisse M van SantenDepartment of Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa (CBMSO/CSIC), Madrid, Spain.ORCID 0000-0003-0769-4511
Santos MañesDepartment of Immunology and Oncology, Centro Nacional de Biotecnología (CNB/CSIC), Madrid, Spain.ORCID 0000-0001-8023-957X
Centro de Biología Molecular Severo Ochoa · ESCentro Nacional de Biotecnología · ESInstituto de Salud Carlos III · ESUniversity of Freiburg · DECentro Andaluz de Biología del Desarrollo · ESFundació ACE · ESHospital Universitario de Valme · ESUniversidad Pontificia Comillas · ES
Funding
FAMILY THERAPY VS TRADITIONAL THERAPY FOR DRUG ABUSERSR01DA003733 · NIDA · TEXAS TECH UNIVERSITY · PI JOANNING, HARVEY · 1985 to 1988
–Comunidad de Madrid (Madrid Autonomous Community) B2017/BMD-3733Deutsche Forschungsgemeinschaft (DFG) BIOSS-EXC294Deutsche Forschungsgemeinschaft (DFG) CIBSS-EXC 2189Deutsche Forschungsgemeinschaft (DFG) SCHA976/7-1Deutsche Forschungsgemeinschaft (DFG) SFB1381"la Caixa" Foundation ("la Caixa")MEC | Instituto de Salud Carlos III (ISCIII) PI13/02434MEC | Instituto de Salud Carlos III (ISCIII) PI16/01861Merck Salud FoundationMinisterio de Ciencia, Innovación y Universidades (Ministry of Science, Innovation and Universities) CTQ2017-85378-RMinisterio de Ciencia, Innovación y Universidades (Ministry of Science, Innovation and Universities) FIS2016-78883-C2-2-PMinisterio de Ciencia, Innovación y Universidades (Ministry of Science, Innovation and Universities) SAF2017-83732-R
Abstract
CCR5 is not only a coreceptor for HIV-1 infection in CD4
Indexed as
Immunologic MemoryAnimalsAntigensCD4-Positive T-LymphocytesCeramidesHEK293 CellsHumansMiceMice, KnockoutReceptors, CCR5AntigensCCR5 protein, humanCCR5 protein, mouseCeramidesReceptors, CCR5ccr5[delta]32humoral responsemembrane phasesphingolipidT-cell receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.