ArticleAmerican journal of clinical pathology2020
CALIPER Hematology Reference Standards (II).
Article in American journal of clinical pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Examination of elevated myocardial extracellular volume and exercise capacity in pediatric Fontan patients at moderate altitude.Pediatric radiology · 2026Article
- A new prediction diagnosis model of incomplete Kawasaki disease based on data mining with big data.Pediatric discovery · 2025Article
- Five-Year Experience of Etanercept as Adjunct to Intravenous Immunoglobulin for Kawasaki Disease with Coronary Artery Involvement.Journal of pediatrics. Clinical practice · 2025Article
- Hematological reference intervals for adult population of Debre Berhan town, North East Ethiopia.Scientific reports · 2025Article
- Article
- Increased MCHC*RDW-SD interaction values: indicators of neurological impairment in lead-poisoned children.PeerJ · 2024Article
- Hemoglobin and Its Z Score Reference Intervals in Febrile Children: A Cohort Study of 98,572 Febrile Children.Children (Basel, Switzerland) · 2023Article
- Differentinating between non-transfusion dependant β-thalassemia and iron deficinecy anemia in children using ROC and logistic regression analysis: two novel discrimination indices designed for pediatric patients.Frontiers in pediatrics · 2023Article
- Indirect reference intervals for haematological parameters in capillary blood of pre-school children.Biochemia medica · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe objective of this study was to establish comprehensive age- and sex-specific reference intervals for hematologic parameters in the CALIPER cohort of healthy children and adolescents.
methodsA total of 536 healthy children and adolescents (birth to 21 years) were recruited with informed consent, and whole blood samples were analyzed for 27 hematologic parameters on the Beckman Coulter DxH 520 system. Age- and sex-specific pediatric reference standards were established. Reference values obtained on the DxH 520 were also compared with data obtained on a larger laboratory-based instrument (DxH 900).
resultsMost hematologic parameters showed significant age- and/or sex-specific changes during growth and development. Of the 27 hematologic parameters, all except four (mean corpuscular hemoglobin concentration, basophil percentage, low hemoglobin density, immature cell percentage) required age partitioning, and eight required sex partitioning.
conclusionsThis study establishes a robust pediatric hematology reference database that will assist in more accurate test result interpretation. Our data clearly demonstrate significant variation in hematologic parameter concentrations in children and adolescents, necessitating the use of pediatric-specific reference standards.
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