Evidence map›Paper›PMID 32525305›Full record

ArticleJournal of the American Society for Mass Spectrometry2020

Collision Cross Section Conformational Analyses of Bile Acids via Ion Mobility-Mass Spectrometry.

James C Poland, Katrina L Leaptrot, Stacy D Sherrod, Charles Robb Flynn, John A McLean

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

James C PolandCenter for Innovative Technology, Department of Chemistry, Institute of Chemical Biology, Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0003-1506-7251
Katrina L LeaptrotCenter for Innovative Technology, Department of Chemistry, Institute of Chemical Biology, Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0002-9266-145X
Stacy D SherrodCenter for Innovative Technology, Department of Chemistry, Institute of Chemical Biology, Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0002-2346-230X
Charles Robb FlynnDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37235, United States.
John A McLeanCenter for Innovative Technology, Department of Chemistry, Institute of Chemical Biology, Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID http://orcid.org/0000-0001-8918-6419
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Bile Diversion: A Simple and Effective Method of Treating ObesityR01DK105847 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ABUMRAD, NAJI N, FLYNN, CHARLES R · 2015 to 2019
$1.8M
Ion mobility based informatics and visualization strategies in support of metabolomicsR03CA222452 · NCI · VANDERBILT UNIVERSITY · PI MCLEAN, JOHN ALAN · 2017 to 2017
$152k
NCI NIH HHS R03 CA222452NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK105847
6 · The paper itself

Abstract

Bile acids serve as one of the most important classes of biological molecules in the gastrointestinal system. Due to their structural similarity, bile acids have historically been difficult to accurately annotate in complex biological matrices using mass spectrometry. They often have identical or nominally similar mass-to-charge ratios and similar fragmentation patterns that make identification by mass spectrometry arduous, normally involving chemical derivatization and separation via liquid chromatography. Here, we demonstrate the use of drift tube ion mobility (DTIM) to derive collision cross section (CCS) values in nitrogen drift gas (

Identifiers

PMID32525305
PMCPMC8059067
OpenAlexW3033217834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.