Evidence map›Paper›PMID 32525238›Full record

ArticleAnnals of neurology2020

Association between Pregnancy and Cervical Artery Dissection.

Setareh Salehi Omran, Neal S Parikh, Sharon Poisson, Jennifer Armstrong, Alexander E Merkler, Malavika Prabhu, Babak B Navi, Laura E Riley, Matthew E Fink, Hooman Kamel

Abstract read
In one paragraph

Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Article
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  12. Review
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  14. Article
  15. Pregnancy and stroke risk in women.Neurobiology of disease · 2022
    Article
  16. The Impact of Sex and Gender on Stroke.Circulation research · 2022
    Review
  17. Article
  18. Cervical Artery Dissections: Etiopathogenesis and Management.Vascular health and risk management · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Setareh Salehi OmranClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-3184-5327
Neal S ParikhClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8802-2380
Sharon PoissonDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
Jennifer ArmstrongDepartment of Pediatrics (Neurology) and Obstetrics and Gynecology, University of Colorado Anschutz School of Medicine & Children's Hospital Colorado, Denver, CO, USA.
Alexander E MerklerClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
Malavika PrabhuDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Babak B NaviClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-8424-6128
Laura E RileyDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Matthew E FinkClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
Hooman KamelClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-5745-0307

Funding

MRI Detection of CarotId Plaques as a mecHanism for Embolic strokes of undeteRmined source (MRI DECIPHER)R01HL144541 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, KAMEL, HOOMAN · 2019 to 2023
$3.9M
Stroke Trials Network of Columbia and CornellU24NS107237 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EDWARD SANDER CONNOLLY, Randolph S Marshall · 2018 to 2026
$3.1M
Left Atrial abNormality, ThromboEmbolism, and Race: Novel risk factors for stroke (LANTERN)R01NS097443 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KAMEL, HOOMAN · 2016 to 2019
$1.5M
Cancer And Risk Of Ischemic StrokeK23NS091395 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI NAVI, BABAK BENJAMIN · 2015 to 2019
$945k
NHLBI NIH HHS R01 HL144541NINDS NIH HHS K23 NS091395NINDS NIH HHS K23NS091395NINDS NIH HHS R01HL144541NINDS NIH HHS R01 NS097443NINDS NIH HHS R01NS097443NINDS NIH HHS U24 NS107237NINDS NIH HHS U24NS107237
6 · The paper itself

Abstract

objectiveWe wanted to determine whether pregnancy is associated with cervical artery dissection.

methodsWe performed a case-control study using claims data from all nonfederal emergency departments and acute care hospitals in New York and Florida between 2005 and 2015. Cases were women 12-42 years of age hospitalized with cervical artery dissection, defined using validated diagnosis codes for carotid/vertebral artery dissection. Controls were women 12-42 years of age with a primary diagnosis of renal colic. Cases and controls were matched 1:1 on age, race, insurance, income, state, and visit year. The exposure variable was pregnancy, defined as labor and delivery within 90 days before or 6 months after the index visit. Logistic regression was used to compare the odds of pregnancy between cases and controls. We performed a secondary cohort-crossover study comparing the risk of cervical artery dissection during pregnancy versus the same time period 1 year later.

resultsPregnancy was twice as common among 826 women with cervical artery dissection compared with the 826 matched controls with renal colic (odds ratio, 2.5; 95% confidence interval [CI], 1.3-4.7). In our secondary analysis, pregnancy was associated with a higher risk of cervical artery dissection (incidence rate ratio [IRR], 2.2; 95% CI, 1.3-3.5), with the heightened risk limited to the postpartum period (IRR, 5.5; 95% CI, 2.6-11.7).

interpretationPregnancy, specifically the postpartum period, was associated with hospitalization for cervical artery dissection. Although these findings might in part reflect ascertainment bias, our results suggest that arterial dissection is one mechanism by which pregnancy can lead to stroke. ANN NEUROL 2020;88:596-602.

Indexed as

AdolescentAdultCarotid Artery, Internal, DissectionCase-Control StudiesChildFemaleHumansPregnancyPregnancy ComplicationsVertebral Artery DissectionYoung Adult

Identifiers

PMID32525238
PMCPMC10001425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.