ReviewInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2020
Progesterone and preterm birth.
Review in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.Neonatology · 2023Guideline
- New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems.Advanced healthcare materials · 2026Article
- Evaluation of Methods Adjusting for Unmeasured Confounding Using Large Healthcare Databases: An Empirical Study Concerning Drugs Inducing Prematurity.Clinical and translational science · 2025Article
- A Combination ofNutrients · 2025Article
- Progesterone regulation of cervix ripening in preterm and term birth in mice.Reproduction (Cambridge, England) · 2025Article
- Longitudinal urine metabolic profiling and gestational age prediction in human pregnancy.Briefings in bioinformatics · 2024Article
- A genome scale transcriptional regulatory model of the human placenta.Science advances · 2024Article
- Internet-Based Interventions for Preventing Premature Birth Among Pregnant Women: Systematic Review.JMIR pediatrics and parenting · 2024Review
- Animal models of postpartum hemorrhage.Lab animal · 2024Review
- Early prediction of spontaneous preterm birth before 34 gestational weeks based on a combination of inflammation-associated plasma proteins.Frontiers in immunology · 2024Article
- Screening and prevention of preterm birth: how is it done in clinical practice?Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Effects of Prenatal Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, on Offspring's Health: Evidence from Epidemiological and Experimental Studies.Biomolecules · 2023Review
- Article
- A Novel Predictive Machine Learning Model Integrating Cytokines in Cervical-Vaginal Mucus Increases the Prediction Rate for Preterm Birth.International journal of molecular sciences · 2023Article
- Increased Survival Concomitant with Unchanged Morbidity and Cognitive Disability among Infants Born at the Limit of Viability before 24 Gestational Weeks in 2009-2019.Journal of clinical medicine · 2023Article
- Article
- Maternal Plasma RNA in First Trimester Nullipara for the Prediction of Spontaneous Preterm Birth ≤ 32 Weeks: Validation Study.Biomedicines · 2023Article
- Contributors to Preterm Birth: Data from a Single Polish Perinatal Center.Children (Basel, Switzerland) · 2023Article
- Identification of potential therapeutic intervening targets by in-silico analysis of nsSNPs in preterm birth-related genes.PloS one · 2023Article
- Application of Artificial Intelligence in Screening for Adverse Perinatal Outcomes-A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Progestogens (vaginal progesterone and intramuscular 17-hydroxyprogesterone acetate) are widely recommended for women at high risk of preterm birth. Typical regimens include 17-hydroxyprogesterone caproate (250 mg intramuscularly weekly), starting at 16-20 gestational weeks until 36 weeks or delivery for women with a singleton gestation and a history of spontaneous preterm birth, or vaginal progesterone (90-mg vaginal gel or 200-mg micronized vaginal soft capsules) for women with a short cervix (typically ≤25 mm). Although some randomized trials support this approach, neither of the largest trials (PROLONG for 17-hydroxyprogesterone acetate or OPPTIMUM for vaginal progesterone) demonstrated efficacy. There are almost no data on long-term effects, and none that shows benefit beyond the neonatal period. Although some analyses suggest the cost-effectiveness of the approach, a cervical length screening program followed by progesterone for those with a short cervix will reduce preterm birth rates by less than 0.5%. The present review assesses evidence on the efficacy, likely impact, and long-term effects of implementing the recommendations for progestogens in full. Clinicians and pregnant women can look forward to resolution of the conflicting views on efficacy once the Patient-Centered Outcomes Research Initiative (PCORI)-funded individual patient data meta-analysis is published.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.