ArticleJournal of industrial microbiology & biotechnology2020
Enhanced production of β-alanine through co-expressing two different subtypes of L-aspartate-α-decarboxylase.
Article in Journal of industrial microbiology & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Recent Advances in Beta-Alanine Production via Enzymatic Catalysis and Microbial Whole-Cell Catalysis.Biology · 2026Review
- Immobilization of hydroaminase-expressing recombinant Escherichia coli whole-cell biocatalysts for the production of β-alanine.Biotechnology letters · 2026Article
- One-Pot Synthesis of β-Alanine from Fumaric Acid via an Efficient Dual-Enzyme Cascade Biotransformation.Biomolecules · 2024Article
- Discovery and Engineering of a Novel Bacterial L-Aspartate α-Decarboxylase for Efficient Bioconversion.Foods (Basel, Switzerland) · 2023Article
- MpADC, an L-aspartate-α-decarboxylase, from Myzus persicae, that enables production of β-alanine with high yield by whole-cell enzymatic catalysis.Biotechnology for biofuels and bioproducts · 2023Article
- Development of probiotic E. coli Nissle 1917 for β-alanine production by using protein and metabolic engineering.Applied microbiology and biotechnology · 2023Article
- Metabolic engineering to improve production of 3-hydroxypropionic acid from corn-stover hydrolysate in Aspergillus species.Biotechnology for biofuels and bioproducts · 2023Article
- Advances in the synthesis of β-alanine.Frontiers in bioengineering and biotechnology · 2023Review
- Study on the construction technology of β-alanine synthesizingFrontiers in bioengineering and biotechnology · 2023Article
- Fatty acid feedstocks enable a highly efficient glyoxylate-TCA cycle for high-yield production of β-alanine.mLife · 2022Article
- Enhancement of β-Alanine Biosynthesis inBiology · 2021Article
- Metabolic engineering of methylotrophic Pichia pastoris for the production of β-alanine.Bioresources and bioprocessing · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
β-Alanine (β-Ala) is an important intermediate with numerous applications in food and feed additives, pharmaceuticals, polymeric materials, and electroplating industries. Its biological production routes that employ L-aspartate-α-decarboxylase (ADC) as the key enzyme are attractive. In this study, we developed an efficient and environmentally safe method for β-Ala production by co-expressing two different subtypes of ADC. A bacterial ADC from Bacillus subtilis (BSADC) and an insect ADC from Tribolium castaneum (TCADC) use pyruvoyl and pyridoxal-5'-phosphate (PLP) as cofactor, respectively. 3050 mM (271.5 g/L) β-Ala was achieved from L-aspartic acid by using the whole-cell biocatalyst co-expressing BSADC and TCADC, corresponding to a conversion rate of 92.4%. Meanwhile, one-pot synthesis of β-Ala from fumaric acid through using a tri-enzyme cascade route with two different subtypes of ADC and L-aspartase (AspA) from Escherichia coli was established. 2250 mM (200.3 g/L) β-Ala was obtained from fumaric acid with a conversion rate of 90.0%. This work proposes a novel strategy that improves β-Ala production in the decarboxylation pathway of L-aspartic acid.
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