Evidence map›Paper›PMID 32524422›Full record

ArticleJournal of neurovirology2020

Evidence for a novel subcortical mechanism for posterior cingulate cortex atrophy in HIV peripheral neuropathy.

John R Keltner, Alan Tong, Eelke Visser, Mark Jenkinson, Colm G Connolly, Alyssa Dasca, Aleks Sheringov, Zachary Calvo, Earl Umbao, Rohit Mande and 12 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

John R KeltnerDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA. jkeltner@ucsd.edu.ORCID 0000-0002-4076-7033
Alan TongDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Eelke VisserWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
Mark JenkinsonWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
Alyssa DascaDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Aleks SheringovDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Zachary CalvoDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Earl UmbaoDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Rohit MandeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Mary Beth BilderDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Gagandeep SahotaDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Donald R FranklinDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Stephanie CorkranDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Igor GrantDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Sarah ArchibaldDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Florin VaidaDepartment of Family and Preventative Medicine, University of California San Diego, San Diego, CA, USA.
Gregory G BrownDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
J Hampton AtkinsonDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Alan N SimmonsDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Ronald J EllisDepartments of Neurosciences and Psychiatry, University of California San Diego, San Diego, CA, USA.
CHARTER Group
University of California San Diego · USUniversity of Oxford · GBFlorida State University · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
Role of evolving white matter damage in neurocognitive effects of HIV and HCVR01MH079752 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2007 to 2011
$1.9M
Pain Mechanisms for New Onset and Chronic HIV Distal Neuropathic PainK23NS079311 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELTNER, JOHN R · 2013 to 2017
$749k
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIDA NIH HHS P50 DA026306NIMH NIH HHS HHSN271201000027CNIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH079752NIMH NIH HHS R01 MH107345NIMH NIH HHS R25 MH081482NINDS NIH HHS K23 NS079311
6 · The paper itself

Abstract

We previously reported that neuropathic pain was associated with smaller posterior cingulate cortical (PCC) volumes, suggesting that a smaller/dysfunctional PCC may contribute to development of pain via impaired mind wandering. A gap in our previous report was lack of evidence for a mechanism for the genesis of PCC atrophy in HIV peripheral neuropathy. Here we investigate if volumetric differences in the subcortex for those with neuropathic paresthesia may contribute to smaller PCC volumes, potentially through deafferentation of ascending white matter tracts resulting from peripheral nerve damage in HIV neuropathy. Since neuropathic pain and paresthesia are highly correlated, statistical decomposition was used to separate pain and paresthesia symptoms to determine which regions of brain atrophy are associated with both pain and paresthesia and which are associated separately with pain or paresthesia. HIV+ individuals (N = 233) with and without paresthesia in a multisite study underwent structural brain magnetic resonance imaging. Voxel-based morphometry and a segmentation/registration tool were used to investigate regional brain volume changes associated with paresthesia. Analysis of decomposed variables found that smaller midbrain and thalamus volumes were associated with paresthesia rather than pain. However, atrophy in the PCC was related to both pain and paresthesia. Peak thalamic atrophy (p = 0.004; MNI x = - 14, y = - 24, z = - 2) for more severe paresthesia was in a region with reciprocal connections with the PCC. This provides initial evidence that smaller PCC volumes in HIV peripheral neuropathy are related to ascending white matter deafferentation caused by small fiber damage observed in HIV peripheral neuropathy.

Indexed as

AdultAgedAtrophyBrain MappingCross-Sectional StudiesFemaleGyrus CinguliHIVHIV InfectionsHumansMagnetic Resonance ImagingMaleMiddle AgedNeuralgiaParesthesiaPeripheral Nervous System DiseasesBrainHIVImagingParesthesiaPeripheral neuropathy

Identifiers

PMID32524422
PMCPMC7442648
OpenAlexW3033581462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.