ArticlePediatric nephrology (Berlin, Germany)2021
Torque teno viral load reflects immunosuppression in paediatric kidney-transplanted patients-a pilot study.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review.European journal of clinical investigation · 2025Pooled it
- Torque teno virus load as marker of rejection and infection in solid organ transplantation - A systematic review and meta-analysis.Reviews in medical virology · 2023Pooled it
- Trial
- Growth and development following paediatric kidney transplantation: Mechanisms, influencing factors, and clinical management.World journal of transplantation · 2026Review
- Immune monitoring by Torque Teno virus load in addition to virus-specific T cells after pediatric kidney transplantation.Clinical kidney journal · 2026Article
- Biomarkers related to immunosuppression in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026Article
- TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging.Journal of medical virology · 2025Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Immune Monitoring Goes Viral - Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Torque Teno Virus-Guided Immunosuppression in Kidney Transplantation: Expanding the Application.Kidney international reports · 2024Article
- Torque Teno Virus (TTV)-A Potential Marker of Immunocompetence in Solid Organ Recipients.Viruses · 2023Review
- Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease.Current microbiology · 2023Review
- Viral load of Torquetenovirus correlates with Sano's score and levels of total bilirubin and aspartate aminotransferase in Kawasaki disease.Scientific reports · 2023Article
- Current Status Regarding Immunosuppressive Treatment in Patients after Renal Transplantation.International journal of molecular sciences · 2023Review
- Identification of Torquetenovirus Species in Patients with Kawasaki Disease Using a Newly Developed Species-Specific PCR Method.International journal of molecular sciences · 2023Article
- Understanding torquetenovirus (TTV) as an immune marker.Frontiers in medicine · 2023Review
- Association of torque teno virus viremia with liver fibrosis in the first year after liver transplantation.Frontiers in immunology · 2023Article
- Association of post-transplantation anellovirus viral load with kidney transplant rejection in children.Pediatric nephrology (Berlin, Germany) · 2022Article
- Application of metagenomic next-generation sequencing in the diagnosis and treatment of recurrent urinary tract infection in kidney transplant recipients.Frontiers in public health · 2022Article
- Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the COVID-19 Pandemic.Frontiers in public health · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic deterioration of kidney graft function is related to inadequate immunosuppression (IS). A novel tool to assess the individual net state of IS in transplanted patients might be the monitoring of Torque teno virus (TTV) viral load. TTV is a non-pathogen virus detectable in almost all individuals. TTV level in the peripheral blood has been linked to the immune-competence of its host and should thus reflect IS after solid organ transplantation.
methodsTTV plasma load was quantified monthly by RT-PCR for a period of 1 year in 45 kidney-transplanted children. Post-transplant time was at least 3 months. The relation of the virus DNA levels to IS and transplant-specific clinical and laboratory parameters was analysed longitudinally.
resultsTTV DNA was detectable in 94.5% of the plasma samples. There was a significant association with the post-transplant follow-up time as well as with the type of IS regimen, with lower virus loads in patients after longer post-transplant time and mTOR inhibitor-based IS. Furthermore, a significant positive correlation with the dose of prednisolone and mycophenolate mofetil was found.
conclusionsTTV levels show an association/correlation with the strength of IS. Further studies are needed in order to evaluate TTV measurement as a tool for IS monitoring for hard clinical outcomes such as presence of donor-specific antibodies, rejections or infections-common consequences of insufficient or too intense IS.
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