Evidence map›Paper›PMID 32524226›Full record

Trial reportEuropean journal of applied physiology2020

Hypoxic training improves blood pressure, nitric oxide and hypoxia-inducible factor-1 alpha in hypertensive patients.

Nattha Muangritdech, Michael J Hamlin, Kittisak Sawanyawisuth, Piya Prajumwongs, Wisutthida Saengjan, Preetiwat Wonnabussapawich, Nuttaset Manimmanakorn, Apiwan Manimmanakorn

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Hypoxic Pilates Intervention for Obesity: A Randomized Controlled Trial.International journal of environmental research and public health · 2020
    Trial
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Intermittent hypoxia: a call for harmonization in terminology.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  19. Review
  20. Ventilatory Pattern Influences Tolerance to Normobaric Hypoxia in Healthy Adults.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nattha MuangritdechDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Michael J HamlinDepartment of Tourism, Sport and Society, Lincoln University, Lincoln, New Zealand.
Kittisak SawanyawisuthDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Piya PrajumwongsDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Wisutthida SaengjanDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Preetiwat WonnabussapawichSport and Exercise Science Program, Faculty of Science and Technology, Nakhonratchasima Rajabhat University, Nakhon Ratchasima, Thailand.
Nuttaset ManimmanakornDepartment of Rehabilitation, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Apiwan ManimmanakornDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. mapiwa@kku.ac.th.ORCID http://orcid.org/0000-0002-0927-9453
Khon Kaen University · THLincoln University · NZNakhon Ratchasima Rajabhat University · TH

Funding

Khon Kaen University IN61142
6 · The paper itself

Abstract

purposeTo examine the effects of intermittent hypoxic breathing at rest (IHR) or during exercise (IHT) on blood pressure and nitric oxide metabolites (NOx) and hypoxia-inducible factor-1 alpha levels (HIF-1α) over a 6-week period.

methods47 hypertensive patients were randomly allocated to three groups: hypertensive control (CON: n = 17; IHR: n = 15 and IHT: n = 15. The CON received no intervention; whereas, IH groups received eight events of hypoxia (F

resultsWe observed a significant decrease of the SBP in both IH groups: IHR (- 12.0 ± 8.0 mmHg, p = 0.004 and - 9.9 ± 8.8 mmHg, p = 0.028, mean ± 95% CI) and IHT (- 13.0 ± 7.8 mmHg, p = 0.002 and - 10.0 ± 8.4 mmHg, p = 0.016) at days 2 and 28 post-intervention, respectively. Compared to CON, IHR and IHT had increased of NOx (IHR; 8.5 ± 7.6 μmol/L, p = 0.031 and IHT; 20.0 ± 9.1 μmol/L, p < 0.001) and HIF-1α (IHR; 170.0 ± 100.0 pg/mL, p = 0.002 and IHT; 340.5 ± 160.0 pg/mL, p < 0.001). At 2 days post-intervention, NOx and HIF-1α were negatively correlated with SBP in IHT.

conclusionIH programs may act as an alternative therapeutic strategy for hypertension patients probably through elevation of NOx and HIF-1α production.

Indexed as

AdultBlood PressureBreathing ExercisesExercise TherapyFemaleHumansHypertensionHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedNitric OxideRespirationHypoxia-Inducible Factor 1, alpha SubunitNitric OxideExerciseHypoxicatorMalondialdehydeNitrite/nitrateSimulated altitudeSix-minute walk test

Identifiers

PMID32524226
OpenAlexW3033627854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.