ArticleScience advances2020
Three-dimensional DNA tweezers serve as modular DNA intelligent machines for detection and regulation of intracellular microRNA.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
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- Fluorescent sensing of tsRNA by silver nanoclusters with exponential amplification-mediated DNA tetrahedron.Mikrochimica acta · 2025Article
- Tetrahedral-modified magnetic nanorobotic probe for enhanced imaging of cancer-related miRNA.Microsystems & nanoengineering · 2025Article
- SplintR ligation-triggeredPeerJ · 2025Article
- Reconfigurable Amphiphilic DNA Nanotweezer for Targeted Delivery of Therapeutic Oligonucleotides.ACS central science · 2024Article
- Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine.Chemical reviews · 2024Review
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- Temporal logic circuits implementation using a dual cross-inhibition mechanism based on DNA strand displacement.RSC advances · 2023Article
- Mechanics of dynamic and deformable DNA nanostructures.Chemical science · 2023Review
- A Smart Nano-Theranostic Platform Based on Dual-microRNAs Guided Self-Feedback Tetrahedral Entropy-Driven DNA Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A stimulus-responsive hexahedron DNA framework facilitates targeted and direct delivery of native anticancer proteins into cancer cells.Chemical science · 2022Article
- Programming a DNA tetrahedral nanomachine as an integrative tool for intracellular microRNA biosensing and stimulus-unlocked target regulation.Materials today. Bio · 2022Article
- A multiplexed circulating tumor DNA detection platform engineered from 3D-coded interlocked DNA rings.Bioactive materials · 2022Article
- Asymmetric patterning drives the folding of a tripodal DNA nanotweezer.Chemical science · 2021Article
- Bioorthogonal regulation of DNA circuits for smart intracellular microRNA imaging.Chemical science · 2021Article
- Cascade Strand Displacement and Bipedal Walking Based DNA Logic System for miRNA Diagnostics.ACS central science · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) as novel biological targets are hardly applied in diagnostic and treatment of diseases, as they are difficult to be accurately detected and regulated. Here, we demonstrated a modular DNA intelligent machine named three-dimensional tweezers (TD-tweezers) to image and regulate miRNAs in living cells simultaneously. Fluorophore or miRNA inhibitors are introduced as detecting or regulating parts to construct different types of TD-tweezers, and the conformational state of TD-tweezers is controlled by the target miRNAs. The TD-tweezers exhibit excellent sensitivity, specificity, stability, and biocompatibility in vitro and in vivo, and their function of regulating miRNAs was confirmed by the up-regulated expression of downstream genes and proteins. Moreover, the TD-tweezers have been tested in whole blood, preliminarily verifying their clinical application potential. This design provides a multifunctional platform that can achieve efficient detection and regulation of targets within living cells and promote the development of DNA intelligent machines.
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