Evidence map›Paper›PMID 32523992›Full record

ArticleScience advances2020

Physiology-forward identification of bile acid-sensitive vomeronasal receptors.

Wen Mai Wong, Jie Cao, Xingjian Zhang, Wayne I Doyle, Luis L Mercado, Laurent Gautron, Julian P Meeks

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  5. Article
  6. Review
  7. Review
  8. Article
  9. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen Mai WongDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0001-6451-2812
Jie CaoDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0002-1518-5381
Xingjian ZhangDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0003-3131-5761
Wayne I DoyleDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0001-8276-2591
Luis L MercadoDivision of Hypothalamic Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0001-6362-7968
Laurent GautronDivision of Hypothalamic Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0003-3609-7441
Julian P MeeksDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA.ORCID 0000-0002-7537-4491

Funding

Mammalian bile acid detection, processing, and impact on social behaviorR01DC017985 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI MEEKS, JULIAN P · 2019 to 2023
$2.2M
Inhibitory processing and social learning in the mouse accessory olfactory bulbR01DC015784 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI MEEKS, JULIAN P · 2017 to 2021
$1.8M
Investigating information processing in parallel circuits that link external chemical signals to social behaviorR21NS104826 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI MEEKS, JULIAN P · 2017 to 2018
$421k
Inhibitory Processing and Social Learning in the Mouse Accessory Olfactory BulbR56DC015784 · NIDCD · UNIVERSITY OF ROCHESTER · PI MEEKS, JULIAN P · 2023 to 2023
$382k
Investigating bile acid detection and processing in the mouse accessory olfactory systemF31DC017661 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI WONG, WEN MAI · 2018 to 2020
$94k
NIDCD NIH HHS F31 DC017661NIDCD NIH HHS R01 DC015784NIDCD NIH HHS R01 DC017985NIDCD NIH HHS R56 DC015784NINDS NIH HHS R21 NS104826
6 · The paper itself

Abstract

The mouse accessory olfactory system (AOS) supports social and reproductive behavior through the sensation of environmental chemosignals. A growing number of excreted steroids have been shown to be potent AOS cues, including bile acids (BAs) found in feces. As is still the case with most AOS ligands, the specific receptors used by vomeronasal sensory neurons (VSNs) to detect BAs remain unknown. To identify VSN BA receptors, we first performed a deep analysis of VSN BA tuning using volumetric GCaMP6f/s Ca

Identifiers

PMID32523992
PMCPMC7259934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.