Evidence map›Paper›PMID 32523971›Full record

ReviewOpen forum infectious diseases2020

A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated

Michael Dagher, Vance G Fowler, Patty W Wright, Milner B Staub

Registry-linked trialAbstract readReview
In one paragraph

Review in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04544306 (Partial Oral Antimicrobial Versus Intravenous Antimicrobial Therapy to Treat Infective Endocarditis in People Who Inject Drugs), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04544306 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Partial Oral Antimicrobial Versus Intravenous Antimicrobial Therapy to Treat Infective Endocarditis in People Who Inject Drugs

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2021 to 2025Enrolled50ConditionsInfective EndocarditisArmsPartial oral antimicrobial therapy
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Transitioning to oral therapy compared to IV inAnnals of medicine and surgery (2012) · 2025
    Article
  5. Early Oral Antibiotic Switch in Staphylococcus aureus Bacteraemia: The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Early Oral Switch Protocol.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  6. Review
  7. Contemporary Management of Staphylococcus aureus Bacteremia-Controversies in Clinical Practice.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
  8. Article
  9. Persistent Methicilin-Resistant Staphylococcus aureus Bacteremia: Resetting the Clock for Optimal Management.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael DagherDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
Vance G FowlerDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
Patty W WrightDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Milner B StaubDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

Mentoring Patient Oriented Research in Antibiotic-Resistant BacteriaK24AI093969 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2011 to 2020
$1.6M
NIAID NIH HHS K24 AI093969
6 · The paper itself

Abstract

Historically, intravenous (IV) antibiotics have been the cornerstone of treatment for uncomplicated

Indexed as

antimicrobialsbacteremiaoral administrationStaphylococcus aureusstep-down therapy

Identifiers

PMID32523971
PMCPMC7270708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.