Evidence map›Paper›PMID 32523888›Full record

ReviewEuropean thyroid journal2020

Physiologic Significance of Epigenetic Regulation of Thyroid Hormone Target Gene Expression.

João Anselmo, Carolina M Chaves

Open access · bronzeAbstract readReview
In one paragraph

Review in European thyroid journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Actions of thyroid hormones and thyromimetics on the liver.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Thyroid hormone signaling in the intestinal stem cells and their niche.Cellular and molecular life sciences : CMLS · 2022
    Review
  6. Review
  7. Article
  8. ZFP36L2 Role in Thyroid Functionality.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

João AnselmoDepartment of Endocrinology and Nutrition, Hospital Divino Espírito Santo, Ponta Delgada, Portugal.
Carolina M ChavesDepartment of Endocrinology and Nutrition, Hospital Divino Espírito Santo, Ponta Delgada, Portugal.
Hospital do Divino Espírito Santo · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn previous publications, we have reported our findings demonstrating that exposure to high maternal levels of thyroid hormones (TH) has life-long effects on the wild-type (WT, without

objectivesWe reviewed the mechanisms involved in the epigenetic regulation of TH target genes and understand how they may explain the reduced sensitivity to TH in the WT progeny of RTHβ mothers.

methodsThe availability of a large, formerly genotyped Azorean population with many individuals harboring the

resultsThe thyroid-stimulating hormone (TSH) response in WT adults was less suppressible following the administration of L-triiodothyronine (L-T

conclusionIncreased D3 expression and consequently increased T

Indexed as

Deiodinase type 3Epigenetic regulationResistance to thyroid hormone betaTransgenerational inheritance

Identifiers

PMID32523888
PMCPMC7265707
OpenAlexW3013410088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.