ArticleTherapeutic advances in endocrinology and metabolism2020
Demonstration of reciprocal diurnal variation in human serum T3 and rT3 concentration demonstrated by mass spectrometric analysis and establishment of thyroid hormone reference intervals.
Article in Therapeutic advances in endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 12 citations in OpenAlex.
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and serum thyroid function measures: Recent Findings from NHANES 2007-2012 and Mendelian randomization.Frontiers in endocrinology · 2025Article
- Thyroid Hormone Reference Intervals among Healthy Individuals In Lanzhou, China.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin.Thyroid : official journal of the American Thyroid Association · 2021Article
- The effect of specific binding proteins on immunoassay measurements of total and free thyroid hormones and cortisol.Therapeutic advances in endocrinology and metabolism · 2021Article
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Authors and funding
10 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundThere has been a wide range of reference intervals proposed in previous literature for thyroid hormones due to large between-assay variability of immunoassays, as well as lack of correction for collection time. We provided the diurnal reference intervals for five thyroid hormones, namely total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and reverse T3 (rT3), measured in serum samples of healthy participants using a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method.
methodsCouplet serum samples (a.m. and p.m.) were collected from 110 healthy females and 49 healthy males. Healthy volunteers were recruited from four participating centers between 2016 and 2018. Measurements of thyroid hormones were obtained by LC-MS/MS analysis.
resultsOur study revealed significant uptrend in AM to PM FT4 (
conclusionWhen diagnosing thyroid disorders, it is important to have accurate measurement of thyroid hormones, and to acknowledge the diurnal fluctuation found, especially for FT3. Our study highlights the importance of standardization of collection times and implementation of LC-MS/MS in thyroid hormone measurement.
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