Evidence map›Paper›PMID 32523548›Full record

ArticleFrontiers in physiology2020

Renal Programming by Transient Postnatal Overfeeding: The Role of Senescence Pathways.

Christian Juvet, Benazir Siddeek, Catherine Yzydorczyk, Catherine Vergely, Katya Nardou, Jean-Baptiste Armengaud, Mohamed Benahmed, Umberto Simeoni, François Cachat, Hassib Chehade

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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  3. Geroprotective effects of GdVOBiogerontology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Christian JuvetDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Benazir SiddeekDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Catherine YzydorczykDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Catherine VergelyInserm UMR866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (LPPCM), Faculties of Medicine and Pharmacy, University of Burgundy, Dijon, France.
Katya NardouDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Jean-Baptiste ArmengaudDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Mohamed BenahmedDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Umberto SimeoniDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
François CachatDivision of Pediatrics, Pediatric Nephrology Unit, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Hassib ChehadeDivision of Pediatrics, Developmental Origins of Health and Disease (DOHaD) Laboratory, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
University Hospital of Lausanne · CHUniversity of Lausanne · CHUniversité de Bourgogne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly nutrition influences the risk of chronic kidney diseases (CKDs) development in adulthood. Mechanisms underlying the early programming of altered renal function remain incompletely understood. This study aims at characterizing the role of cell senescence pathways in early programming of CKD after transient postnatal overfeeding. MATERIALS AND

methodsReduced litters of 3 mice pups and standard litters of 9 mice pups were obtained to induce overfed animals during lactation and control animals, respectively. Animals were sacrificed at 24 days (weaning) or at 7 months of life (adulthood). Body weight, blood pressure, kidney weight, and glomerular count were assessed in both groups. Senescence pathways were investigated using β-Galactosidase staining and Western blotting of P16, P21, P53, P-Rb/Rb, and Sirtuin 1 (Sirt1) proteins.

resultsEarly overfed animals had a higher body weight, a higher blood pressure at adulthood, and a higher glomerular number endowment compared to the control group. A higher β-Galactosidase activity, a significant increase in P53 protein expression (

conclusionEarly postnatal overfeeding by litter size reduction is associated with increased expression of factors involved in cellular senescence pathways, and decreased expression of Sirt 1 in the mouse kidney at weaning. These alterations may contribute to CKD programming after early postnatal overfeeding.

Indexed as

chronic kidney diseasedevelopmental origins of health and diseasekidneyovernutritionpostnatal overfeedingprogramming

Identifiers

PMID32523548
PMCPMC7261937
OpenAlexW3029527659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.