Evidence map›Paper›PMID 32523508›Full record

SynthesisFrontiers in neuroscience2020

Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis-a Systematic Review and Meta-Analysis of Preclinical Research.

Elizabeth Elliott, Olivia Bailey, Fergal M Waldron, Giles E Hardingham, Siddharthan Chandran, Jenna M Gregory

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Molecular and pharmacological chaperones for SOD1.Biochemical Society transactions · 2020
    Review
  10. Homeostatic Roles of the Proteostasis Network in Dendrites.Frontiers in cellular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Elizabeth ElliottUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Olivia BaileyCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.
Fergal M WaldronAshworth Laboratories, Institute of Evolutionary Biology and Centre for Immunity Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom.
Giles E HardinghamUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Siddharthan ChandranUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Jenna M GregoryUK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
UK Dementia Research Institute · GBCentre for Immunity, Infection and Evolution · GBInstitute for Stem Cell Biology and Regenerative Medicine · INMRC Centre for Regenerative Medicine · GBUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

amyotrophic lateral sclerosismeta-analysismotor neurone diseasepreclinicalproteostasissurvivalsystematic reviewtherapeutic

Identifiers

PMID32523508
PMCPMC7261930
OpenAlexW3028540379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.