Evidence map›Paper›PMID 32523427›Full record

ArticleCancer cell international2020

Preoperative systemic immune-inflammation index predicts prognosis of patients with non-metastatic renal cell carcinoma: a propensity score-matched analysis.

Xu Hu, Yan-Xiang Shao, Zhi-Qiang Yang, Wei-Chao Dou, San-Chao Xiong, Xiang Li

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Article in Cancer cell international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

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26citing papers in PubMed, 4 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xu Hu *West China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041 People's Republic of China.
Yan-Xiang Shao *West China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041 People's Republic of China.
Zhi-Qiang Yang *West China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041 People's Republic of China.
Wei-Chao DouWest China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041 People's Republic of China.
San-Chao XiongWest China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041 People's Republic of China.
Xiang LiDepartment of Urology, West China Hospital, West China Medical School, Sichuan University, 37 Guoxue Street, Chengdu, 610041 People's Republic of China.ORCID 0000-0003-0765-1546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA novel systemic immune-inflammation index (SII), based on the neutrophils, lymphocytes and platelet counts, is associated with the prognosis of several cancers. The present study evaluates the prognostic significance of SII in non-metastatic renal cell carcinoma (RCC).

methodThe present study retrospectively reviewed the medical record of patients with non-metastatic RCC who underwent nephrectomy between 2010 and 2013. Receiver operating characteristic (ROC) curve analysis was performed to identify the optimal cut-off value. In addition, the propensity score matching (PSM) was performed with a matching ratio of 1:1. Univariate and multivariate Cox proportional hazards models were used to identify the prognostic factors. The results were reported by hazard ratio (HR) with 95% confidence interval (95% CI).

resultsA total of 646 patients were included in the final analysis. High SII group (> 529) was significantly associated with older age (P = 0.014), larger tumor (P < 0.001), higher pathological T stage (P < 0.001), higher tumor grade (P < 0.001) and more tumor necrosis (P < 0.001). Multivariate Cox regression analysis demonstrated that the higher preoperative SII was significantly associated with worse overall survival (OS) (HR = 2.26; 95% CI 1.44-3.54; P < 0.001) and cancer-specific survival (CSS) (HR = 2.17; 95% CI 1.33-3.55; P = 0.002). After PSM, elevated preoperative SII was an independent predictor of poor OS (HR = 1.78; 95% CI 1.1-2.87; P = 0.018) and CSS (HR = 1.8; 95% CI 1.07-3.03; P = 0.027).

conclusionIn conclusion, preoperative SII is associated with adverse factors for RCC. Furthermore, higher preoperative SII is an independent predictor of poor OS and CSS in surgically treated patients with non-metastatic RCC. More prospective and large scale studies are warranted to validate our findings.

Indexed as

Non-metastaticPrognosisRenal cell carcinomaSystemic immune-inflammation index

Identifiers

PMID32523427
PMCPMC7281921

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