Evidence map›Paper›PMID 32523377›Full record

ArticleCancer management and research2020

The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7.

Weiqiang Guo, Bin Xu, Xiaoxiao Wang, Bo Zheng, Jiahui Du, Songbai Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Weiqiang GuoSchool of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215009, People's Republic of China.
Bin XuSchool of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215009, People's Republic of China.
Xiaoxiao WangSuzhou Key Laboratory for Medical Biotechnology, Suzhou Vocational Health College, Suzhou 215009, People's Republic of China.
Bo ZhengSchool of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou 215009, People's Republic of China.
Jiahui DuSuzhou Key Laboratory for Medical Biotechnology, Suzhou Vocational Health College, Suzhou 215009, People's Republic of China.
Songbai LiuSuzhou Key Laboratory for Medical Biotechnology, Suzhou Vocational Health College, Suzhou 215009, People's Republic of China.ORCID 0000-0002-3920-1032
Suzhou University of Science and Technology · CNSuzhou Vocational Health College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrsolic acid (UA), a primary bioactive triterpenoid, was reported as an anti-cancer agent. However, the current knowledge of UA and its potential anti-cancer mechanisms and targets in breast cancer cells are limited. In this study, we aimed to illustrate the potential mechanisms and targets of UA in breast cancer cells MCF-7.

methodsThe effect of UA on cell growth was determined in MCF-7 cells by MTT assay. The anti-tumor mechanism of UA was evaluated by microarray, CAMP, and Western blot. Moreover, the molecular docking between UA and potential receptors were predicted by iGEMDOCK software.

resultsThe result of MTT assay demonstrated that UA could inhibit MCF-7 cell growth with IC

conclusionOur data indicated that the anti-tumor effects of UA are due to the inhibited RAF/ERK pathway and IKK/NF-κB pathway. It could also be explained by the reduced phosphorylation of PLK1 in MCF-7 cells. This study provides a new insight for deep understanding of the new anti-cancer mechanisms of UA in MCF-7 breast cancer cells.

Indexed as

connectivity mapIKK/NF-κBPLK1RAF/ERKursolic acid

Identifiers

PMID32523377
PMCPMC7237111
OpenAlexW3024036338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.